Synaptic adhesion molecules and PSD-95

Kihoon Han, Eunjoon Kim

Research output: Contribution to journalReview articlepeer-review

124 Citations (Scopus)


Synaptic adhesion molecules are known to participate in various steps of synapse development including initial contacts between dendrites and axons, formation of early synapses, and their maturation and plastic changes. Notably, a significant subset of synaptic adhesion molecules associates with synaptic scaffolding proteins, suggesting that they may act in concert to couple trans-synaptic adhesion to molecular organization of synaptic proteins. Here, we describe an emerging group of synaptic adhesion molecules that directly interact with the abundant postsynaptic scaffold PSD-95, which include neuroligins, NGLs, SALMs, and ADAM22, and discuss how these proteins and PSD-95 act together to regulate synaptic development. PSD-95 may be one of the central organizers of synaptic adhesion that recruits diverse proteins to sites of synaptic adhesion, promotes trans-synaptic signaling, and couples neuronal activity with changes in synaptic adhesion.

Original languageEnglish
Pages (from-to)263-283
Number of pages21
JournalProgress in Neurobiology
Issue number3
Publication statusPublished - 2008 Mar
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by the Creative Research Initiative Program of the Korean Ministry of Science and Technology (to E.K.).

Copyright 2009 Elsevier B.V., All rights reserved.


  • ADAM22
  • NGL
  • Netrin-G
  • Neurexin
  • Neuroligin
  • PSD-95
  • SALM
  • Synapse

ASJC Scopus subject areas

  • General Neuroscience


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