Abstract
Synaptonemal complex protein 3 is a marker for cell transformation that has prognostic significance in various cancers. However, the prognostic significance of synaptonemal complex protein 3 has not been studied in non-small cell lung cancer. To investigate the potential correlation between synaptonemal complex protein 3 and various clinicopathologic parameters, we assessed the expression of synaptonemal complex protein 3 in archival tumor tissues from 258 patients with non-small cell lung cancer by immunohistochemical staining. By immunofluorescence, synaptonemal complex protein 3 was detected in both the cytoplasmic and nuclear fractions of NCI-H1299 cell. In tumor samples, synaptonemal complex protein 3 is detected as cytoplasmic expression pattern and observed in 50 clinical samples (19.4%) by immunohistochemical staining. Synaptonemal complex protein 3 expression was correlated with T status (P =.008), lymph node metastasis (P =.010), tumor types (P =.019), and pleural invasion (P =.005). In multivariate analysis of patients with early stage disease, increased synaptonemal complex protein 3 expression predicted worse overall survival in early stage (stage I and II) with pT1 status (P =.041). These results suggest that positive synaptonemal complex protein 3 expression is a portent of poor outcome and may be a potential biomarker in the early stages of the non-small cell lung cancer for survival and may provide clues in the identification of patients for adjuvant therapy.
Original language | English |
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Pages (from-to) | 472-479 |
Number of pages | 8 |
Journal | Human Pathology |
Volume | 44 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2013 Apr |
Bibliographical note
Funding Information:This research was supported, in part, by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research.
Keywords
- Immunohistochemistry
- Non-small cell lung cancer
- Prognostic marker
- Synaptonemal complex protein 3
- Tissue microarray
ASJC Scopus subject areas
- Pathology and Forensic Medicine