Synaptonemal complex protein 3 as a novel prognostic marker in early stage non-small cell lung cancer

Joon Yong Chung, Haruhisa Kitano, Mikiko Takikita, Hanbyoul Cho, Kyung Hee Noh, Tae Woo Kim, Kris Ylaya, Jun Hanaoka, Junya Fukuoka, Stephen M. Hewitt

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


Synaptonemal complex protein 3 is a marker for cell transformation that has prognostic significance in various cancers. However, the prognostic significance of synaptonemal complex protein 3 has not been studied in non-small cell lung cancer. To investigate the potential correlation between synaptonemal complex protein 3 and various clinicopathologic parameters, we assessed the expression of synaptonemal complex protein 3 in archival tumor tissues from 258 patients with non-small cell lung cancer by immunohistochemical staining. By immunofluorescence, synaptonemal complex protein 3 was detected in both the cytoplasmic and nuclear fractions of NCI-H1299 cell. In tumor samples, synaptonemal complex protein 3 is detected as cytoplasmic expression pattern and observed in 50 clinical samples (19.4%) by immunohistochemical staining. Synaptonemal complex protein 3 expression was correlated with T status (P =.008), lymph node metastasis (P =.010), tumor types (P =.019), and pleural invasion (P =.005). In multivariate analysis of patients with early stage disease, increased synaptonemal complex protein 3 expression predicted worse overall survival in early stage (stage I and II) with pT1 status (P =.041). These results suggest that positive synaptonemal complex protein 3 expression is a portent of poor outcome and may be a potential biomarker in the early stages of the non-small cell lung cancer for survival and may provide clues in the identification of patients for adjuvant therapy.

Original languageEnglish
Pages (from-to)472-479
Number of pages8
JournalHuman Pathology
Issue number4
Publication statusPublished - 2013 Apr

Bibliographical note

Funding Information:
This research was supported, in part, by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research.


  • Immunohistochemistry
  • Non-small cell lung cancer
  • Prognostic marker
  • Synaptonemal complex protein 3
  • Tissue microarray

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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