Synergistic effects of functional additives on the physico-mechanical and biological properties of poly(L-lactic acid) composites for cardiovascular implant applications

Eun Young Kang, Bogyu Choi, Wooram Park, Ik Hwan Kim, Dong Keun Han

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Statement of Purpose: Biodegradable poly(L-lactic acid) (PLLA) has been widely used as a promising material for vascular stents. Thermal processing is necessary to manufacture PLLA for cardiovascular stents. However, PLLA is vulnerable to thermal degradation when processed at high temperature. Undesired decrease of molecular weight caused by depolymerization reactions not only reduces the mechanical properties after implantation, but also accelerates the degradation rate in body.1 In addition, the acidic environment induced by byproducts of the degraded PLLA matrix leads an inflammatory response to the implanted site. Magnesium hydroxide (MH) nanoparticles have been used as a mechanical reinforcing agent and pH neutralizing agent for biomaterials, such as PLLA.2 In this study, bulk modification of PLLA was performed with addition of thermal stabilizers, plasticizer, and MH nanoparticles to improve their thermal and mechanical properties and suppress acidic byproduct-induced inflammatory response. We believe that the bulk modification of biodegradable PLLA using functional additives will have great potential in various biomedical applications.

    Original languageEnglish
    Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
    Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
    PublisherSociety for Biomaterials
    Pages464
    Number of pages1
    ISBN (Electronic)9781510883901
    Publication statusPublished - 2019
    Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
    Duration: 2019 Apr 32019 Apr 6

    Publication series

    NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
    Volume40
    ISSN (Print)1526-7547

    Conference

    Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
    Country/TerritoryUnited States
    CitySeattle
    Period19/4/319/4/6

    Bibliographical note

    Publisher Copyright:
    © 2019 Omnipress - All rights reserved.

    ASJC Scopus subject areas

    • Biochemistry
    • Biophysics
    • Biotechnology
    • Biomaterials
    • Materials Chemistry

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