Abstract
We report the synthesis of 3-phenethylazetidine derivatives 2 and their biological activities against 5-HT, NE and DA transporters as well as microsomal stability, CYP inhibition, and hERG inhibition profiles. Compound 2at showed most potent triple reuptake inhibitor with good selectivity as a candidate for depression.
Original language | English |
---|---|
Pages (from-to) | 3234-3237 |
Number of pages | 4 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 24 |
Issue number | 15 |
DOIs | |
Publication status | Published - 2014 Aug 1 |
Keywords
- 3-Phenethylazetidines
- Antidepressant
- Depression
- Triple reuptake inhibitor
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry