Synthesis and Characterization of Anguibactin to Reveal Its Competence to Function as a Thermally Stable Surrogate Siderophore for a Gram-Negative Pathogen, Acinetobacter baumannii

Haeun Lee, Woon Young Song, Minju Kim, Min Wook Lee, Soojeung Kim, Ye Song Park, Kyungwon Kwak, Man Hwan Oh, Hak Joong Kim

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Total synthesis of anguibactin was accomplished for the first time, and the following biochemical characterizations allowed for the determination of its Fe(III) binding mode as well as the demonstration of its iron delivery capability for Acinetobacter baumannii. These properties, in addition to the thermal stability over acinetobactin, render anguibactin as a competent surrogate siderophore that can be useful for the future development of a siderophore-based antibiotic delivery system against A. baumannii.

Original languageEnglish
Pages (from-to)6476-6479
Number of pages4
JournalOrganic Letters
Volume20
Issue number20
DOIs
Publication statusPublished - 2018 Oct 19

Bibliographical note

Funding Information:
This study was supported by grants from the National Research Foundation of Korea (NRF-2015R1D1A1A01-056815, NRF2010-0020209) and the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (Grant Number: HI17C1657). K.K. is also thankful for the support from IBS-R023-D1.

Publisher Copyright:
© 2018 American Chemical Society.

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Synthesis and Characterization of Anguibactin to Reveal Its Competence to Function as a Thermally Stable Surrogate Siderophore for a Gram-Negative Pathogen, Acinetobacter baumannii'. Together they form a unique fingerprint.

Cite this