Asymmetrical cis-5,6-dimethyl-6-oxyacetoxy-(2,3)(9,10)-dibenzo-16-crown-5 was synthesized by a multi-step sequence and its stereochemistry determined by NOE experiments. Introduction of the 6-methyl group markedly reduces the stability constant for complexation of Na+ and K+ by the ionized form of the lariat ether carboxylic acid.
Bibliographical noteFunding Information:
This research was supported by the Division of Chemical Sciences of the Office of Basic Sciences of the US department of Energy through grant DE-FG03-94ER14416.
- Crown ether
ASJC Scopus subject areas
- Food Science
- Condensed Matter Physics