Synthesis and evaluation of (4-chlorobenzhydryl) piperazine amides as sodium channel Nav1.7 inhibitors

Keyphrases

• Amides 100%
• Neuropathic Pain 100%
• Piperazine 100%
• Nav1.7 Inhibitor 100%
• Nav1.7 100%
• Sodium Channel Nav1.7 100%
• Inhibitory Activity 50%
• IC50 Value 50%
• Blockage 50%
• Analgesic 50%
• Therapeutic Potential 50%
• Selective Inhibitor 50%
• Fluorescence Imaging 50%
• Anticonvulsant 50%
• Amide Derivatives 50%
• Fluorescence Dye 50%
• Active Compounds 50%
• Clinical Reports 50%
• Carbamazepine 50%
• HEK293 Cell Line 50%
• Drug Discovery 50%
• Pain Treatment 50%
• Lidocaine 50%
• Ion Probe 50%
• Pain Conditions 50%
• Voltage-gated Sodium Channel 50%
• Voltage Sensor 50%
• Topical Anesthetics 50%
• Lamotrigine 50%
• HNav1.7 50%
• Image Plate 50%
• Plate Reader Assay 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Carboxamide 100%
• Neuropathic Pain 100%
• Piperazine 100%
• Sodium Channel Nav1.7 100%
• Fluorescent Dye 50%
• Analgesic Agent 50%
• IC50 50%
• Local Anesthetic Agent 50%
• Drug Discovery 50%
• Lidocaine 50%
• Voltage Gated Sodium Channel 50%
• Lamictal 50%
• Carbamazepine 50%
• Anticonvulsant Therapy 50%