Synthesis and evaluation of benzoquinolinone derivatives as SARS-CoV 3CL protease inhibitors

Tae Young Ahn, Chih Jung Kuo, Hun Ge Liu, Deok Chan Ha, Po Huang Liang, Young Sik Jung

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


For the discovery of new antivirals against Severe Acute Respiratory Syndrome-coronavirus (SARS-CoV), we prepared and evaluated several benzoquinoline compounds as its 3C-like protease (3CLpro) inhibitors. Based on the computer modeling study that each of the two rigid benzoquinolinone and N-phenoltetrazole moieties of the compound 1 is bound to the S1 and S2 sites, respectively, of the SARS protease by forming H-bonds and hydrophobic interactions, we designed and synthesized alkylated benzoquinolines at both the sites of the hydroxyl groups. We found that the compound 2a showed five times higher inhibiting activity against the 3CLpro compared to the compound 1.

Original languageEnglish
Pages (from-to)87-91
Number of pages5
JournalBulletin of the Korean Chemical Society
Issue number1
Publication statusPublished - 2010 Jan


  • 3C protease
  • Benzoquinoline
  • Computer modeling
  • Coronavirus
  • Picornavirus

ASJC Scopus subject areas

  • General Chemistry


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