Synthesis and evaluation of hyaluronic acid-poly(ethylene oxide) hydrogel via Michael-type addition reaction

Gun Woo Kim; Yoon Jeong Choi; Mi Sook Kim; Yongdoo Park; Kyu Back Lee; In Sook Kim; Soon Jung Hwang; Insup Noh

doi:10.1016/j.cap.2006.11.009

Synthesis and evaluation of hyaluronic acid-poly(ethylene oxide) hydrogel via Michael-type addition reaction

Gun Woo Kim, Yoon Jeong Choi, Mi Sook Kim, Yongdoo Park, Kyu Back Lee, In Sook Kim, Soon Jung Hwang, Insup Noh

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Hyaluronic acid-based hydrogel was synthesized by reacting hyaluronic acid with aminopropyl methacrylate and then with poly(ethylene oxide). Gelation was observed within 5.5 h with a rheometer by employing viscous and elastic modulus. While the hydrogel was analyzed by light and electron microscopy for morphological observation, other analysis was performed by Fourier-transformed infrared and electron spectroscopy for chemical analysis. Understanding of a putative reaction scheme was outlined by reference to N-(3-diethylpropyl)-N-ethylcarbodiimide hydrochloride for acrylation of hyaluronic acid and by a Michael-type reaction between methacrylate in aminopropyl methacrylate and thiol arms in PEO end groups.

Original language	English
Pages (from-to)	e28-e32
Journal	Current Applied Physics
Volume	7
Issue number	SUPPL.1
DOIs	https://doi.org/10.1016/j.cap.2006.11.009
Publication status	Published - 2007 Apr

Keywords

Evaluation
Hyaluronic acid
In situ hydrogel
Poly(ethylene oxide)

ASJC Scopus subject areas

Materials Science(all)
Physics and Astronomy(all)

Access to Document

10.1016/j.cap.2006.11.009

Cite this

@article{ea9400fa85c54e6d8877bbb8e3dd4e2b,

title = "Synthesis and evaluation of hyaluronic acid-poly(ethylene oxide) hydrogel via Michael-type addition reaction",

abstract = "Hyaluronic acid-based hydrogel was synthesized by reacting hyaluronic acid with aminopropyl methacrylate and then with poly(ethylene oxide). Gelation was observed within 5.5 h with a rheometer by employing viscous and elastic modulus. While the hydrogel was analyzed by light and electron microscopy for morphological observation, other analysis was performed by Fourier-transformed infrared and electron spectroscopy for chemical analysis. Understanding of a putative reaction scheme was outlined by reference to N-(3-diethylpropyl)-N-ethylcarbodiimide hydrochloride for acrylation of hyaluronic acid and by a Michael-type reaction between methacrylate in aminopropyl methacrylate and thiol arms in PEO end groups.",

keywords = "Evaluation, Hyaluronic acid, In situ hydrogel, Poly(ethylene oxide)",

author = "Kim, {Gun Woo} and Choi, {Yoon Jeong} and Kim, {Mi Sook} and Yongdoo Park and Lee, {Kyu Back} and Kim, {In Sook} and Hwang, {Soon Jung} and Insup Noh",

note = "Funding Information: This project was supported by the Korea Science and Engineering Foundation (R01-2003-000-11592-0).",

year = "2007",

month = apr,

doi = "10.1016/j.cap.2006.11.009",

language = "English",

volume = "7",

pages = "e28--e32",

journal = "Current Applied Physics",

issn = "1567-1739",

publisher = "Elsevier",

number = "SUPPL.1",

}

TY - JOUR

T1 - Synthesis and evaluation of hyaluronic acid-poly(ethylene oxide) hydrogel via Michael-type addition reaction

AU - Kim, Gun Woo

AU - Choi, Yoon Jeong

AU - Kim, Mi Sook

AU - Park, Yongdoo

AU - Lee, Kyu Back

AU - Kim, In Sook

AU - Hwang, Soon Jung

AU - Noh, Insup

N1 - Funding Information: This project was supported by the Korea Science and Engineering Foundation (R01-2003-000-11592-0).

PY - 2007/4

Y1 - 2007/4

N2 - Hyaluronic acid-based hydrogel was synthesized by reacting hyaluronic acid with aminopropyl methacrylate and then with poly(ethylene oxide). Gelation was observed within 5.5 h with a rheometer by employing viscous and elastic modulus. While the hydrogel was analyzed by light and electron microscopy for morphological observation, other analysis was performed by Fourier-transformed infrared and electron spectroscopy for chemical analysis. Understanding of a putative reaction scheme was outlined by reference to N-(3-diethylpropyl)-N-ethylcarbodiimide hydrochloride for acrylation of hyaluronic acid and by a Michael-type reaction between methacrylate in aminopropyl methacrylate and thiol arms in PEO end groups.

AB - Hyaluronic acid-based hydrogel was synthesized by reacting hyaluronic acid with aminopropyl methacrylate and then with poly(ethylene oxide). Gelation was observed within 5.5 h with a rheometer by employing viscous and elastic modulus. While the hydrogel was analyzed by light and electron microscopy for morphological observation, other analysis was performed by Fourier-transformed infrared and electron spectroscopy for chemical analysis. Understanding of a putative reaction scheme was outlined by reference to N-(3-diethylpropyl)-N-ethylcarbodiimide hydrochloride for acrylation of hyaluronic acid and by a Michael-type reaction between methacrylate in aminopropyl methacrylate and thiol arms in PEO end groups.

KW - Evaluation

KW - Hyaluronic acid

KW - In situ hydrogel

KW - Poly(ethylene oxide)

UR - http://www.scopus.com/inward/record.url?scp=33847159143&partnerID=8YFLogxK

U2 - 10.1016/j.cap.2006.11.009

DO - 10.1016/j.cap.2006.11.009

M3 - Article

AN - SCOPUS:33847159143

SN - 1567-1739

VL - 7

SP - e28-e32

JO - Current Applied Physics

JF - Current Applied Physics

IS - SUPPL.1

ER -

Synthesis and evaluation of hyaluronic acid-poly(ethylene oxide) hydrogel via Michael-type addition reaction

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this