Synthesis and micellization behavior of stimuli-responsive polypeptide hybrid triblock copolymer

Jingyi Rao; Zhiyuan Zhu; Shiyong Liu

doi:10.1007/s11434-009-0244-x

Synthesis and micellization behavior of stimuli-responsive polypeptide hybrid triblock copolymer

Jingyi Rao, Zhiyuan Zhu, Shiyong Liu

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Polypeptide hybrid triblock copolymer, poly(L-glutamic acid)-b- poly(propylene oxide)-b-poly (L-glutamic acid) (PLGA-b-PPO-b-PLGA), was synthesized by the ring-opening polymerization of benzyl-L-glutamic N-carboxyanhydride (BLG-NCA) using poly(propylene glycol) bis(2-aminopropyl ether) as initiator, followed by the subsequent deprotection step. The obtained double hydrophilic triblock copolymer exhibits "schizophrenic" micellization behavior in aqueous solution upon dually playing with solution pH and temperature. The multi-responsive micellization behavior of this polypeptide hybrid triblock copolymer has been thoroughly investigated by ¹H NMR, laser light scattering (LLS), temperature-dependent optical transmittance, and circular dichroism spectroscopy (CD).

Original language	English
Pages (from-to)	1912-1917
Number of pages	6
Journal	Chinese Science Bulletin
Volume	54
Issue number	11
DOIs	https://doi.org/10.1007/s11434-009-0244-x
Publication status	Published - 2009 Jun

Keywords

Coil
Micellization
Poly(L-glutamic acid)
Poly(propylene glycol)
α-helix

ASJC Scopus subject areas

General

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10.1007/s11434-009-0244-x

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title = "Synthesis and micellization behavior of stimuli-responsive polypeptide hybrid triblock copolymer",

abstract = "Polypeptide hybrid triblock copolymer, poly(L-glutamic acid)-b- poly(propylene oxide)-b-poly (L-glutamic acid) (PLGA-b-PPO-b-PLGA), was synthesized by the ring-opening polymerization of benzyl-L-glutamic N-carboxyanhydride (BLG-NCA) using poly(propylene glycol) bis(2-aminopropyl ether) as initiator, followed by the subsequent deprotection step. The obtained double hydrophilic triblock copolymer exhibits {"}schizophrenic{"} micellization behavior in aqueous solution upon dually playing with solution pH and temperature. The multi-responsive micellization behavior of this polypeptide hybrid triblock copolymer has been thoroughly investigated by 1H NMR, laser light scattering (LLS), temperature-dependent optical transmittance, and circular dichroism spectroscopy (CD).",

keywords = "Coil, Micellization, Poly(L-glutamic acid), Poly(propylene glycol), α-helix",

author = "Jingyi Rao and Zhiyuan Zhu and Shiyong Liu",

note = "Funding Information: Received November 10, 2008; accepted January 22, 2009 doi: 10.1007/s11434-009-0244-x †Corresponding author (email: sliu@ustc.edu.cn) Supported by the National Natural Science Foundation 20534020, 20674079, and 20874092)",

year = "2009",

month = jun,

doi = "10.1007/s11434-009-0244-x",

language = "English",

volume = "54",

pages = "1912--1917",

journal = "Science Bulletin",

issn = "2095-9273",

publisher = "Springer Science + Business Media",

number = "11",

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TY - JOUR

T1 - Synthesis and micellization behavior of stimuli-responsive polypeptide hybrid triblock copolymer

AU - Rao, Jingyi

AU - Zhu, Zhiyuan

AU - Liu, Shiyong

N1 - Funding Information: Received November 10, 2008; accepted January 22, 2009 doi: 10.1007/s11434-009-0244-x †Corresponding author (email: sliu@ustc.edu.cn) Supported by the National Natural Science Foundation 20534020, 20674079, and 20874092)

PY - 2009/6

Y1 - 2009/6

N2 - Polypeptide hybrid triblock copolymer, poly(L-glutamic acid)-b- poly(propylene oxide)-b-poly (L-glutamic acid) (PLGA-b-PPO-b-PLGA), was synthesized by the ring-opening polymerization of benzyl-L-glutamic N-carboxyanhydride (BLG-NCA) using poly(propylene glycol) bis(2-aminopropyl ether) as initiator, followed by the subsequent deprotection step. The obtained double hydrophilic triblock copolymer exhibits "schizophrenic" micellization behavior in aqueous solution upon dually playing with solution pH and temperature. The multi-responsive micellization behavior of this polypeptide hybrid triblock copolymer has been thoroughly investigated by 1H NMR, laser light scattering (LLS), temperature-dependent optical transmittance, and circular dichroism spectroscopy (CD).

AB - Polypeptide hybrid triblock copolymer, poly(L-glutamic acid)-b- poly(propylene oxide)-b-poly (L-glutamic acid) (PLGA-b-PPO-b-PLGA), was synthesized by the ring-opening polymerization of benzyl-L-glutamic N-carboxyanhydride (BLG-NCA) using poly(propylene glycol) bis(2-aminopropyl ether) as initiator, followed by the subsequent deprotection step. The obtained double hydrophilic triblock copolymer exhibits "schizophrenic" micellization behavior in aqueous solution upon dually playing with solution pH and temperature. The multi-responsive micellization behavior of this polypeptide hybrid triblock copolymer has been thoroughly investigated by 1H NMR, laser light scattering (LLS), temperature-dependent optical transmittance, and circular dichroism spectroscopy (CD).

KW - Coil

KW - Micellization

KW - Poly(L-glutamic acid)

KW - Poly(propylene glycol)

KW - α-helix

UR - http://www.scopus.com/inward/record.url?scp=67049088225&partnerID=8YFLogxK

U2 - 10.1007/s11434-009-0244-x

DO - 10.1007/s11434-009-0244-x

M3 - Article

AN - SCOPUS:67049088225

SN - 2095-9273

VL - 54

SP - 1912

EP - 1917

JO - Science Bulletin

JF - Science Bulletin

IS - 11

ER -

Synthesis and micellization behavior of stimuli-responsive polypeptide hybrid triblock copolymer

Abstract

Keywords

ASJC Scopus subject areas

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