Synthesis and micellization behavior of stimuli-responsive polypeptide hybrid triblock copolymer

Jingyi Rao, Zhiyuan Zhu, Shiyong Liu

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1 Citation (Scopus)


Polypeptide hybrid triblock copolymer, poly(L-glutamic acid)-b- poly(propylene oxide)-b-poly (L-glutamic acid) (PLGA-b-PPO-b-PLGA), was synthesized by the ring-opening polymerization of benzyl-L-glutamic N-carboxyanhydride (BLG-NCA) using poly(propylene glycol) bis(2-aminopropyl ether) as initiator, followed by the subsequent deprotection step. The obtained double hydrophilic triblock copolymer exhibits "schizophrenic" micellization behavior in aqueous solution upon dually playing with solution pH and temperature. The multi-responsive micellization behavior of this polypeptide hybrid triblock copolymer has been thoroughly investigated by 1H NMR, laser light scattering (LLS), temperature-dependent optical transmittance, and circular dichroism spectroscopy (CD).

Original languageEnglish
Pages (from-to)1912-1917
Number of pages6
JournalChinese Science Bulletin
Issue number11
Publication statusPublished - 2009 Jun


  • Coil
  • Micellization
  • Poly(L-glutamic acid)
  • Poly(propylene glycol)
  • α-helix

ASJC Scopus subject areas

  • General


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