Synthesis and thermally reversible assembly of DNA - Gold nanoparticle cluster conjugates

Ji Young Kim; Jae Seung Lee

doi:10.1021/nl9030709

Synthesis and thermally reversible assembly of DNA - Gold nanoparticle cluster conjugates

Ji Young Kim, Jae Seung Lee

Research output: Contribution to journal › Article › peer-review

85 Citations (Scopus)

Abstract

We describe the facile synthesis of stable gold nanoparticle clusters densely functionalized with DNA (DNA-AuNP clusters) using dithiothreitol and monothiol DNA and their thermally reversible assembly properties. The size of the clusters exhibits a very narrow distribution and can be easily controlled by adjusting the stoichiometry of dithiothreitol and DNA, leading to a variety of colors due to the surface plasmon resonance of the AuNP clusters. Importantly, the DNA-AuNP clusters exhibit highly cooperative melting properties with distinctive and diverse color changes depending on their size. The selective and sensitive colorimetric detection of target sequences was demonstrated based upon the unique properties of the DNA-AuNP clusters.

Original language	English
Pages (from-to)	4564-4569
Number of pages	6
Journal	Nano Letters
Volume	9
Issue number	12
DOIs	https://doi.org/10.1021/nl9030709
Publication status	Published - 2009 Dec 9

ASJC Scopus subject areas

Bioengineering
General Chemistry
General Materials Science
Condensed Matter Physics
Mechanical Engineering

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10.1021/nl9030709

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abstract = "We describe the facile synthesis of stable gold nanoparticle clusters densely functionalized with DNA (DNA-AuNP clusters) using dithiothreitol and monothiol DNA and their thermally reversible assembly properties. The size of the clusters exhibits a very narrow distribution and can be easily controlled by adjusting the stoichiometry of dithiothreitol and DNA, leading to a variety of colors due to the surface plasmon resonance of the AuNP clusters. Importantly, the DNA-AuNP clusters exhibit highly cooperative melting properties with distinctive and diverse color changes depending on their size. The selective and sensitive colorimetric detection of target sequences was demonstrated based upon the unique properties of the DNA-AuNP clusters.",

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AB - We describe the facile synthesis of stable gold nanoparticle clusters densely functionalized with DNA (DNA-AuNP clusters) using dithiothreitol and monothiol DNA and their thermally reversible assembly properties. The size of the clusters exhibits a very narrow distribution and can be easily controlled by adjusting the stoichiometry of dithiothreitol and DNA, leading to a variety of colors due to the surface plasmon resonance of the AuNP clusters. Importantly, the DNA-AuNP clusters exhibit highly cooperative melting properties with distinctive and diverse color changes depending on their size. The selective and sensitive colorimetric detection of target sequences was demonstrated based upon the unique properties of the DNA-AuNP clusters.

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Synthesis and thermally reversible assembly of DNA - Gold nanoparticle cluster conjugates

Abstract

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