A protocol for the synthesis of 2-(2-nitrophenyl)indoline-3-acetic acid derivatives was developed via base-catalyzed cyclization of N-(2-nitrobenzyl)-2-aminocinnamic acid derivatives. The synthetic utility of this methodology was illustrated by the concise synthesis of dihydropaullone, a partially saturated analog of paullone. Furthermore, the indoline scaffold could be further converted to the corresponding indoles and other indole-fused heterocycles.
|Number of pages||6|
|Journal||Organic and Biomolecular Chemistry|
|Publication status||Published - 2023 Jan 27|
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry