Abstract
A protocol for the synthesis of 2-(2-nitrophenyl)indoline-3-acetic acid derivatives was developed via base-catalyzed cyclization of N-(2-nitrobenzyl)-2-aminocinnamic acid derivatives. The synthetic utility of this methodology was illustrated by the concise synthesis of dihydropaullone, a partially saturated analog of paullone. Furthermore, the indoline scaffold could be further converted to the corresponding indoles and other indole-fused heterocycles.
Original language | English |
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Pages (from-to) | 1647-1652 |
Number of pages | 6 |
Journal | Organic and Biomolecular Chemistry |
Volume | 21 |
Issue number | 8 |
DOIs | |
Publication status | Published - 2023 Jan 27 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry