Synthesis of 2-aminoquinoxalines via one-pot cyanide-based sequential reaction under aerobic oxidation conditions

Yeon Ho Cho; Kyung Hee Kim; Cheol Hong Cheon

doi:10.1021/jo4021908

Synthesis of 2-aminoquinoxalines via one-pot cyanide-based sequential reaction under aerobic oxidation conditions

Yeon Ho Cho
, Kyung Hee Kim
, Cheol Hong Cheon^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

A highly efficient synthesis of 2-aminoquinoxalines has been developed via the one-pot two-step cyanide-mediated sequential reactions of ortho-phenylenediamines with aldehydes under aerobic oxidation conditions. A variety of substrates, including aliphatic aldehydes bearing acidic α-protons, are applicable to this protocol and afford the desired 2-aminoquinoxalines in high yields.

Original language	English
Pages (from-to)	901-907
Number of pages	7
Journal	Journal of Organic Chemistry
Volume	79
Issue number	3
DOIs	https://doi.org/10.1021/jo4021908
Publication status	Published - 2014 Feb 7

ASJC Scopus subject areas

Organic Chemistry

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10.1021/jo4021908

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title = "Synthesis of 2-aminoquinoxalines via one-pot cyanide-based sequential reaction under aerobic oxidation conditions",

abstract = "A highly efficient synthesis of 2-aminoquinoxalines has been developed via the one-pot two-step cyanide-mediated sequential reactions of ortho-phenylenediamines with aldehydes under aerobic oxidation conditions. A variety of substrates, including aliphatic aldehydes bearing acidic α-protons, are applicable to this protocol and afford the desired 2-aminoquinoxalines in high yields.",

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AU - Cho, Yeon Ho

AU - Kim, Kyung Hee

AU - Cheon, Cheol Hong

PY - 2014/2/7

Y1 - 2014/2/7

N2 - A highly efficient synthesis of 2-aminoquinoxalines has been developed via the one-pot two-step cyanide-mediated sequential reactions of ortho-phenylenediamines with aldehydes under aerobic oxidation conditions. A variety of substrates, including aliphatic aldehydes bearing acidic α-protons, are applicable to this protocol and afford the desired 2-aminoquinoxalines in high yields.

AB - A highly efficient synthesis of 2-aminoquinoxalines has been developed via the one-pot two-step cyanide-mediated sequential reactions of ortho-phenylenediamines with aldehydes under aerobic oxidation conditions. A variety of substrates, including aliphatic aldehydes bearing acidic α-protons, are applicable to this protocol and afford the desired 2-aminoquinoxalines in high yields.

UR - https://www.scopus.com/pages/publications/84893851639

U2 - 10.1021/jo4021908

DO - 10.1021/jo4021908

M3 - Article

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AN - SCOPUS:84893851639

SN - 0022-3263

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JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 3

ER -

Synthesis of 2-aminoquinoxalines via one-pot cyanide-based sequential reaction under aerobic oxidation conditions

Abstract

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