Synthesis of bioadhesive PHEA hydrogels without crosslinkers through in situ polymerization and sustained mechanical mixing

Seo Yoon Kim, Ji Won Kang, Eun Hui Jeong, Taeho Kim, Ha Lim Jung, Jang Ung Park, Jinhan Cho, Jun Dong Park, Byoung Soo Kim

Research output: Contribution to journalArticlepeer-review

Abstract

Abstract: This study presents a novel methodology for the fabrication of bioadhesives composed of poly(2-hydroxyethyl acrylate) (PHEA), which demonstrate superior mechanical properties. Hydrogels based on PHEA were effectively synthesized through a strategy that obviates the need for crosslinkers, utilizing in situ polymerization of high-concentration 2-hydroxyethyl acrylate (HEA) monomers under persistent agitation. Optimal operational conditions, such as polymerization duration and HEA monomer concentration, were screened through rheological evaluations. In addition, the introduction of glycerol to the PHEA hydrogels yielded improvements in water-retention capacity, thus resolving limitations frequently observed in conventional aqueous-based hydrogels. Tests assessing adhesive properties indicated that the PHEA hydrogels, synthesized without crosslinkers, exhibited exceptional adhesion capabilities that exceeded those of commercially available tissue sealants. This economically viable and readily scalable fabrication technique provides a compelling pathway for the creation of robust, biocompatible bioadhesives well-suited for biomedical utilization. Graphical abstract: (Figure presented.)

Original languageEnglish
Pages (from-to)71-78
Number of pages8
JournalKorea Australia Rheology Journal
Volume36
Issue number1
DOIs
Publication statusPublished - 2024 Feb

Bibliographical note

Publisher Copyright:
© Korean Society of Rheology 2024.

Keywords

  • Bioadhesives
  • Crosslinker-free hydrogel
  • PHEA hydrogel
  • Wound dressing

ASJC Scopus subject areas

  • General Materials Science
  • Condensed Matter Physics

Fingerprint

Dive into the research topics of 'Synthesis of bioadhesive PHEA hydrogels without crosslinkers through in situ polymerization and sustained mechanical mixing'. Together they form a unique fingerprint.

Cite this