Synthesis of DAAS derivatives and their enhancement of HL-60 leukemia cell differentiation

Seung Hyun Kim; Sun Young Chung; Young Wall Kim; Tae Sung Kim; Bo Gil Choi

doi:10.1007/s12272-001-1155-z

Synthesis of DAAS derivatives and their enhancement of HL-60 leukemia cell differentiation

Seung Hyun Kim, Sun Young Chung, Young Wall Kim, Tae Sung Kim, Bo Gil Choi

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

DAAS is the diacetoxy acetal derivative of a-santonin and induces HL-60 cell differentiation into granulocytes. In this report, we investigated the structure-activity relationship (SAR) of DAAS derivatives in the differentiation of human HL-60 leukemia cells. Although its derivatives themselves had less effect on HL-60 cell differentiation than DAAS, the monoacetyl derivative, 2, mainly induced HL-60 cell differentiation. Moreover, compound 2 synergistically enhanced all-trans retinoic acid (ATRA)-induced HL-60 cell differentiation when combined with 50 nM ATRA, a well-known differentiation inducer. This enhancing effect is similar to that of DAAS in ATRA-induced differentiation.

Original language	English
Pages (from-to)	300-304
Number of pages	5
Journal	Archives of pharmacal research
Volume	31
Issue number	3
DOIs	https://doi.org/10.1007/s12272-001-1155-z
Publication status	Published - 2008 Mar

Bibliographical note

Funding Information:
This study was financially supported by Chonnam National University in 2004. Our thanks are due to staff of the Korea Basic Science Institute for NMR measurements.

Keywords

ATRA
DAAS
Leukemia cell differentiation
Santonin

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery
Organic Chemistry

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10.1007/s12272-001-1155-z

Cite this

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title = "Synthesis of DAAS derivatives and their enhancement of HL-60 leukemia cell differentiation",

abstract = "DAAS is the diacetoxy acetal derivative of a-santonin and induces HL-60 cell differentiation into granulocytes. In this report, we investigated the structure-activity relationship (SAR) of DAAS derivatives in the differentiation of human HL-60 leukemia cells. Although its derivatives themselves had less effect on HL-60 cell differentiation than DAAS, the monoacetyl derivative, 2, mainly induced HL-60 cell differentiation. Moreover, compound 2 synergistically enhanced all-trans retinoic acid (ATRA)-induced HL-60 cell differentiation when combined with 50 nM ATRA, a well-known differentiation inducer. This enhancing effect is similar to that of DAAS in ATRA-induced differentiation.",

keywords = "ATRA, DAAS, Leukemia cell differentiation, Santonin",

author = "Kim, {Seung Hyun} and Chung, {Sun Young} and Kim, {Young Wall} and Kim, {Tae Sung} and Choi, {Bo Gil}",

note = "Funding Information: This study was financially supported by Chonnam National University in 2004. Our thanks are due to staff of the Korea Basic Science Institute for NMR measurements.",

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doi = "10.1007/s12272-001-1155-z",

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AU - Kim, Seung Hyun

AU - Chung, Sun Young

AU - Kim, Young Wall

AU - Kim, Tae Sung

AU - Choi, Bo Gil

N1 - Funding Information: This study was financially supported by Chonnam National University in 2004. Our thanks are due to staff of the Korea Basic Science Institute for NMR measurements.

PY - 2008/3

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N2 - DAAS is the diacetoxy acetal derivative of a-santonin and induces HL-60 cell differentiation into granulocytes. In this report, we investigated the structure-activity relationship (SAR) of DAAS derivatives in the differentiation of human HL-60 leukemia cells. Although its derivatives themselves had less effect on HL-60 cell differentiation than DAAS, the monoacetyl derivative, 2, mainly induced HL-60 cell differentiation. Moreover, compound 2 synergistically enhanced all-trans retinoic acid (ATRA)-induced HL-60 cell differentiation when combined with 50 nM ATRA, a well-known differentiation inducer. This enhancing effect is similar to that of DAAS in ATRA-induced differentiation.

AB - DAAS is the diacetoxy acetal derivative of a-santonin and induces HL-60 cell differentiation into granulocytes. In this report, we investigated the structure-activity relationship (SAR) of DAAS derivatives in the differentiation of human HL-60 leukemia cells. Although its derivatives themselves had less effect on HL-60 cell differentiation than DAAS, the monoacetyl derivative, 2, mainly induced HL-60 cell differentiation. Moreover, compound 2 synergistically enhanced all-trans retinoic acid (ATRA)-induced HL-60 cell differentiation when combined with 50 nM ATRA, a well-known differentiation inducer. This enhancing effect is similar to that of DAAS in ATRA-induced differentiation.

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KW - Leukemia cell differentiation

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JO - Archives of pharmacal research

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Synthesis of DAAS derivatives and their enhancement of HL-60 leukemia cell differentiation

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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