Synthesis of DAAS derivatives and their enhancement of HL-60 leukemia cell differentiation

Seung Hyun Kim; Sun Young Chung; Young Wall Kim; Tae Sung Kim; Bo Gil Choi

doi:10.1007/s12272-001-1155-z

Synthesis of DAAS derivatives and their enhancement of HL-60 leukemia cell differentiation

Seung Hyun Kim, Sun Young Chung, Young Wall Kim, Tae Sung Kim, Bo Gil Choi

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

DAAS is the diacetoxy acetal derivative of a-santonin and induces HL-60 cell differentiation into granulocytes. In this report, we investigated the structure-activity relationship (SAR) of DAAS derivatives in the differentiation of human HL-60 leukemia cells. Although its derivatives themselves had less effect on HL-60 cell differentiation than DAAS, the monoacetyl derivative, 2, mainly induced HL-60 cell differentiation. Moreover, compound 2 synergistically enhanced all-trans retinoic acid (ATRA)-induced HL-60 cell differentiation when combined with 50 nM ATRA, a well-known differentiation inducer. This enhancing effect is similar to that of DAAS in ATRA-induced differentiation.

Original language	English
Pages (from-to)	300-304
Number of pages	5
Journal	Archives of pharmacal research
Volume	31
Issue number	3
DOIs	https://doi.org/10.1007/s12272-001-1155-z
Publication status	Published - 2008 Mar

Keywords

ATRA
DAAS
Leukemia cell differentiation
Santonin

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery
Organic Chemistry

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10.1007/s12272-001-1155-z

Cite this

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title = "Synthesis of DAAS derivatives and their enhancement of HL-60 leukemia cell differentiation",

abstract = "DAAS is the diacetoxy acetal derivative of a-santonin and induces HL-60 cell differentiation into granulocytes. In this report, we investigated the structure-activity relationship (SAR) of DAAS derivatives in the differentiation of human HL-60 leukemia cells. Although its derivatives themselves had less effect on HL-60 cell differentiation than DAAS, the monoacetyl derivative, 2, mainly induced HL-60 cell differentiation. Moreover, compound 2 synergistically enhanced all-trans retinoic acid (ATRA)-induced HL-60 cell differentiation when combined with 50 nM ATRA, a well-known differentiation inducer. This enhancing effect is similar to that of DAAS in ATRA-induced differentiation.",

keywords = "ATRA, DAAS, Leukemia cell differentiation, Santonin",

author = "Kim, {Seung Hyun} and Chung, {Sun Young} and Kim, {Young Wall} and Kim, {Tae Sung} and Choi, {Bo Gil}",

note = "Funding Information: This study was financially supported by Chonnam National University in 2004. Our thanks are due to staff of the Korea Basic Science Institute for NMR measurements.",

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doi = "10.1007/s12272-001-1155-z",

language = "English",

volume = "31",

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journal = "Archives of Pharmacal Research",

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TY - JOUR

T1 - Synthesis of DAAS derivatives and their enhancement of HL-60 leukemia cell differentiation

AU - Kim, Seung Hyun

AU - Chung, Sun Young

AU - Kim, Young Wall

AU - Kim, Tae Sung

AU - Choi, Bo Gil

N1 - Funding Information: This study was financially supported by Chonnam National University in 2004. Our thanks are due to staff of the Korea Basic Science Institute for NMR measurements.

PY - 2008/3

Y1 - 2008/3

N2 - DAAS is the diacetoxy acetal derivative of a-santonin and induces HL-60 cell differentiation into granulocytes. In this report, we investigated the structure-activity relationship (SAR) of DAAS derivatives in the differentiation of human HL-60 leukemia cells. Although its derivatives themselves had less effect on HL-60 cell differentiation than DAAS, the monoacetyl derivative, 2, mainly induced HL-60 cell differentiation. Moreover, compound 2 synergistically enhanced all-trans retinoic acid (ATRA)-induced HL-60 cell differentiation when combined with 50 nM ATRA, a well-known differentiation inducer. This enhancing effect is similar to that of DAAS in ATRA-induced differentiation.

AB - DAAS is the diacetoxy acetal derivative of a-santonin and induces HL-60 cell differentiation into granulocytes. In this report, we investigated the structure-activity relationship (SAR) of DAAS derivatives in the differentiation of human HL-60 leukemia cells. Although its derivatives themselves had less effect on HL-60 cell differentiation than DAAS, the monoacetyl derivative, 2, mainly induced HL-60 cell differentiation. Moreover, compound 2 synergistically enhanced all-trans retinoic acid (ATRA)-induced HL-60 cell differentiation when combined with 50 nM ATRA, a well-known differentiation inducer. This enhancing effect is similar to that of DAAS in ATRA-induced differentiation.

KW - ATRA

KW - DAAS

KW - Leukemia cell differentiation

KW - Santonin

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U2 - 10.1007/s12272-001-1155-z

DO - 10.1007/s12272-001-1155-z

M3 - Article

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AN - SCOPUS:46249096032

SN - 0253-6269

VL - 31

SP - 300

EP - 304

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

IS - 3

ER -

Synthesis of DAAS derivatives and their enhancement of HL-60 leukemia cell differentiation

Abstract

Keywords

ASJC Scopus subject areas

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