Synthesis of diacetoxy acetal derivatives of santonin and their enhancing effects on HL-60 leukemia cell differentiation

Seung Hyun Kim; Sun Young Chung; Tae Sung Kim; Bo Gil Choi

doi:10.1007/BF02977466

Synthesis of diacetoxy acetal derivatives of santonin and their enhancing effects on HL-60 leukemia cell differentiation

Seung Hyun Kim, Sun Young Chung, Tae Sung Kim, Bo Gil Choi

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Several diacetoxy acetal analogues have been synthesized from santonin and assessed for their ability of inducing or enhancing the differentiation of human HL-60 leukemia cells. The compounds themselves had little effect on HL-60 cell differentiation. However, three analogues, 2a, 3a, and 5b, synergistically enhanced 1,25-dihydroxyvitamin D₃ [1,25-(OH)₂D ₃]-induced HL-60 cell differentiation when combined with 5 nM of dihydroxyvitamin D₃ [1,25-(OH)₂D₃], a well-known differentiation inducer. Especially, the compound 5b profoundly enhanced the 1,25-(OH)₂D₃]-induced HL-60 cell differentiation.

Original language	English
Pages (from-to)	40-45
Number of pages	6
Journal	Archives of pharmacal research
Volume	29
Issue number	1
DOIs	https://doi.org/10.1007/BF02977466
Publication status	Published - 2006 Jan 31

Keywords

Diacetoxyacetal
Dihydroxyvitamin D
Leukemia cell differentiation
Santonin

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery
Organic Chemistry

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10.1007/BF02977466

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title = "Synthesis of diacetoxy acetal derivatives of santonin and their enhancing effects on HL-60 leukemia cell differentiation",

abstract = "Several diacetoxy acetal analogues have been synthesized from santonin and assessed for their ability of inducing or enhancing the differentiation of human HL-60 leukemia cells. The compounds themselves had little effect on HL-60 cell differentiation. However, three analogues, 2a, 3a, and 5b, synergistically enhanced 1,25-dihydroxyvitamin D3 [1,25-(OH)2D 3]-induced HL-60 cell differentiation when combined with 5 nM of dihydroxyvitamin D3 [1,25-(OH)2D3], a well-known differentiation inducer. Especially, the compound 5b profoundly enhanced the 1,25-(OH)2D3]-induced HL-60 cell differentiation.",

keywords = "Diacetoxyacetal, Dihydroxyvitamin D, Leukemia cell differentiation, Santonin",

author = "Kim, {Seung Hyun} and Chung, {Sun Young} and Kim, {Tae Sung} and Choi, {Bo Gil}",

note = "Funding Information: This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (01-PJ 10-PG6-01GN 16-0005).",

year = "2006",

month = jan,

day = "31",

doi = "10.1007/BF02977466",

language = "English",

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T1 - Synthesis of diacetoxy acetal derivatives of santonin and their enhancing effects on HL-60 leukemia cell differentiation

AU - Kim, Seung Hyun

AU - Chung, Sun Young

AU - Kim, Tae Sung

AU - Choi, Bo Gil

N1 - Funding Information: This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (01-PJ 10-PG6-01GN 16-0005).

PY - 2006/1/31

Y1 - 2006/1/31

N2 - Several diacetoxy acetal analogues have been synthesized from santonin and assessed for their ability of inducing or enhancing the differentiation of human HL-60 leukemia cells. The compounds themselves had little effect on HL-60 cell differentiation. However, three analogues, 2a, 3a, and 5b, synergistically enhanced 1,25-dihydroxyvitamin D3 [1,25-(OH)2D 3]-induced HL-60 cell differentiation when combined with 5 nM of dihydroxyvitamin D3 [1,25-(OH)2D3], a well-known differentiation inducer. Especially, the compound 5b profoundly enhanced the 1,25-(OH)2D3]-induced HL-60 cell differentiation.

AB - Several diacetoxy acetal analogues have been synthesized from santonin and assessed for their ability of inducing or enhancing the differentiation of human HL-60 leukemia cells. The compounds themselves had little effect on HL-60 cell differentiation. However, three analogues, 2a, 3a, and 5b, synergistically enhanced 1,25-dihydroxyvitamin D3 [1,25-(OH)2D 3]-induced HL-60 cell differentiation when combined with 5 nM of dihydroxyvitamin D3 [1,25-(OH)2D3], a well-known differentiation inducer. Especially, the compound 5b profoundly enhanced the 1,25-(OH)2D3]-induced HL-60 cell differentiation.

KW - Diacetoxyacetal

KW - Dihydroxyvitamin D

KW - Leukemia cell differentiation

KW - Santonin

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U2 - 10.1007/BF02977466

DO - 10.1007/BF02977466

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SN - 0253-6269

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JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

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ER -

Synthesis of diacetoxy acetal derivatives of santonin and their enhancing effects on HL-60 leukemia cell differentiation

Abstract

Keywords

ASJC Scopus subject areas

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