Synthesis of diethylhexyl adipate by Candida antarctica lipase-catalyzed esterification

Heejin Kim, Taehoon Kim, Nakyung Choi, Byung Hee Kim, Se Wook Oh, In Hwan Kim

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


Diethylhexyl adipate (DEHA) has been used for various applications in the chemical industry. In particular, DEHA is used as a plasticizer for polyvinyl chloride and its polymers. In this study, DEHA was successfully synthesized via lipase-catalyzed esterification from adipic acid with ethylhexanol in a solvent-free system. An immobilized lipase from Candida antarctica (Novozym 435) was used as a biocatalyst in this reaction. The optimal reaction conditions for the synthesis of DEHA were temperature of 50 °C, an enzyme loading of 5% (based on the total weight of substrate), a vacuum of 6.7 kPa, and a molar ratio 1:2.5 (adipic acid to ethylhexanol). When vacuum was applied, the conversion to DEHA was improved significantly and 100 mol% conversion was obtained within only 3 h under optimal condition.

Original languageEnglish
Pages (from-to)58-62
Number of pages5
JournalProcess Biochemistry
Publication statusPublished - 2019 Mar

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Ltd


  • Adipic acid
  • Diethylhexyl adipate
  • Esterification
  • Novozym 435
  • Plasticizer

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Applied Microbiology and Biotechnology


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