Synthesis of functionalized aryl fluorides using organolithium reagents in flow microreactors

Aiichiro Nagaki; Yuki Uesugi; Heejin Kim; Jun Ichi Yoshida

doi:10.1002/asia.201201191

Synthesis of functionalized aryl fluorides using organolithium reagents in flow microreactors

Aiichiro Nagaki, Yuki Uesugi, Heejin Kim, Jun Ichi Yoshida

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

Flow on: Flow microreactors enable the generation of aryl lithium compounds and subsequent electrophilic fluorination with NFSI and N-fluorosultam. The reaction can be successfully accomplished to synthesize various aryl fluorides involving an electron-withdrawing, an electron-donating, and a sterically hindered functional group in good yields.

Original language	English
Pages (from-to)	705-708
Number of pages	4
Journal	Chemistry - An Asian Journal
Volume	8
Issue number	4
DOIs	https://doi.org/10.1002/asia.201201191
Publication status	Published - 2013 Apr
Externally published	Yes

Keywords

fluorination
lithiation
microreactors
synthetic methods

ASJC Scopus subject areas

General Chemistry
Biochemistry
Organic Chemistry

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10.1002/asia.201201191

Cite this

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abstract = "Flow on: Flow microreactors enable the generation of aryl lithium compounds and subsequent electrophilic fluorination with NFSI and N-fluorosultam. The reaction can be successfully accomplished to synthesize various aryl fluorides involving an electron-withdrawing, an electron-donating, and a sterically hindered functional group in good yields.",

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author = "Aiichiro Nagaki and Yuki Uesugi and Heejin Kim and Yoshida, {Jun Ichi}",

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AU - Nagaki, Aiichiro

AU - Uesugi, Yuki

AU - Kim, Heejin

AU - Yoshida, Jun Ichi

PY - 2013/4

Y1 - 2013/4

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AB - Flow on: Flow microreactors enable the generation of aryl lithium compounds and subsequent electrophilic fluorination with NFSI and N-fluorosultam. The reaction can be successfully accomplished to synthesize various aryl fluorides involving an electron-withdrawing, an electron-donating, and a sterically hindered functional group in good yields.

KW - fluorination

KW - lithiation

KW - microreactors

KW - synthetic methods

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Synthesis of functionalized aryl fluorides using organolithium reagents in flow microreactors

Abstract

Keywords

ASJC Scopus subject areas

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