Abstract
Amides, such as N-benzoylsaccharin, N,N-diBocbenzamide, and N-phenyl-N-tosylbenzamides reacted with Et3N⋅3HF to provide the corresponding acyl fluorides in good yields. The reaction was conducted under environmentally friendly conditions using i-PrOAc as the solvent. Moreover, the reaction was performed at room temperature and did not require a transition-metal catalyst or additives. The methodology showed functional group tolerance toward amines, alkoxy, halides, ketones, esters, and aldehydes. (Figure presented.).
Original language | English |
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Pages (from-to) | 2449-2453 |
Number of pages | 5 |
Journal | Advanced Synthesis and Catalysis |
Volume | 364 |
Issue number | 14 |
DOIs | |
Publication status | Published - 2022 Jul 19 |
Bibliographical note
Funding Information:This research was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (NRF-2021R1 A2 C1005169). Spectral and HRMS data were obtained at the Korea Basic Science Institute, Gwangju center and Daegu center.
Funding Information:
. This research was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (NRF‐2021R1 A2 C1005169). Spectral and HRMS data were obtained at the Korea Basic Science Institute, Gwangju center and Daegu center
Publisher Copyright:
© 2022 Wiley-VCH GmbH.
Keywords
- C−N Bond Cleavage
- N-benzoylsaccharin
- acyl fluorides
- amides
- fluorides
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry