Synthesis of homologated binaphthyl N,P-ligands for Pd-catalyzed asymmetric allylic alkylation

Kyoung Hoon Kim, Chan Kyu Jeong, Do Hoon Kim, Deok Chan Ha

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


2-Pyrrolidinylmethyl-2′-diphenylphosphino-1,1′-binaphthyl has been found to be a highly reactive and enantioselective N,P-ligand in the palladium-catalyzed asymmetric allylic alkylation of 1,3-diphenylpropen-2-yl acetate with dimethyl malonate. This axially chiral binaphthyl-based homologated N,P-ligand can be conveniently prepared from enantiomerically pure binaphthol using a five-step reaction sequence, and provides for efficient asymmetric catalysis using the chirality of the binaphthyl skeleton alone.

Original languageEnglish
Pages (from-to)1688-1692
Number of pages5
JournalTetrahedron Asymmetry
Issue number11
Publication statusPublished - 2006 Jul 17

Bibliographical note

Funding Information:
This work was financially supported by Korea Research Foundation Grant (KRF-2003-015-C00358).

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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