Synthesis of multi-stimuli responsive drug carriers for selective multiple drug release to tumor microenvironments

Hyeon Ung Kim, Dae Gun Choi, Hyun Jee Lee, Min Suk Shim, Ki Wan Bong

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Multi-stimuli responsive drug carriers have been actively researched for controlled drug release in complex tumor microenvironments. In addition to the stimuli responsive drug release, combinatorial chemotherapy is essential to increase therapeutic effects. However, previous studies have shown limitation in the synthesis of multi-compartmental drug carriers that can encapsulate multiple drugs and release each drug in a controlled manner. Here, we report multi-stimuli responsive drug carriers containing pH- and redox-sensitive multicompartments. The drug carriers were created by stop flow lithography that can be used to synthesize multicompartmental particles. The carriers exhibited independent drug release upon exposure to the corresponding stimulus.

    Original languageEnglish
    Title of host publication21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
    PublisherChemical and Biological Microsystems Society
    Pages358-359
    Number of pages2
    ISBN (Electronic)9780692941836
    Publication statusPublished - 2020
    Event21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah, United States
    Duration: 2017 Oct 222017 Oct 26

    Publication series

    Name21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

    Conference

    Conference21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
    Country/TerritoryUnited States
    CitySavannah
    Period17/10/2217/10/26

    Bibliographical note

    Funding Information:
    This work was supported by the National Research Foundation of Korea (NRF-2016R1A5A1010148, ERC).

    Publisher Copyright:
    © 17CBMS-0001.

    Keywords

    • Cancer therapy
    • Drug release
    • Flow lithography
    • Multi-stimuli responsive drug carrier

    ASJC Scopus subject areas

    • Chemical Engineering (miscellaneous)
    • Bioengineering

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