Abstract
Multi-stimuli responsive drug carriers have been actively researched for controlled drug release in complex tumor microenvironments. In addition to the stimuli responsive drug release, combinatorial chemotherapy is essential to increase therapeutic effects. However, previous studies have shown limitation in the synthesis of multi-compartmental drug carriers that can encapsulate multiple drugs and release each drug in a controlled manner. Here, we report multi-stimuli responsive drug carriers containing pH- and redox-sensitive multicompartments. The drug carriers were created by stop flow lithography that can be used to synthesize multicompartmental particles. The carriers exhibited independent drug release upon exposure to the corresponding stimulus.
| Original language | English |
|---|---|
| Title of host publication | 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 358-359 |
| Number of pages | 2 |
| ISBN (Electronic) | 9780692941836 |
| Publication status | Published - 2020 |
| Event | 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah, United States Duration: 2017 Oct 22 → 2017 Oct 26 |
Publication series
| Name | 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 |
|---|
Conference
| Conference | 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 |
|---|---|
| Country/Territory | United States |
| City | Savannah |
| Period | 17/10/22 → 17/10/26 |
Bibliographical note
Funding Information:This work was supported by the National Research Foundation of Korea (NRF-2016R1A5A1010148, ERC).
Publisher Copyright:
© 17CBMS-0001.
Keywords
- Cancer therapy
- Drug release
- Flow lithography
- Multi-stimuli responsive drug carrier
ASJC Scopus subject areas
- Chemical Engineering (miscellaneous)
- Bioengineering
