Synthesis of multi-stimuli responsive drug carriers for selective multiple drug release to tumor microenvironments

Hyeon Ung Kim; Dae Gun Choi; Hyun Jee Lee; Min Suk Shim; Ki Wan Bong

Synthesis of multi-stimuli responsive drug carriers for selective multiple drug release to tumor microenvironments

Hyeon Ung Kim
, Dae Gun Choi
, Hyun Jee Lee
, Min Suk Shim
, Ki Wan Bong^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Multi-stimuli responsive drug carriers have been actively researched for controlled drug release in complex tumor microenvironments. In addition to the stimuli responsive drug release, combinatorial chemotherapy is essential to increase therapeutic effects. However, previous studies have shown limitation in the synthesis of multi-compartmental drug carriers that can encapsulate multiple drugs and release each drug in a controlled manner. Here, we report multi-stimuli responsive drug carriers containing pH- and redox-sensitive multicompartments. The drug carriers were created by stop flow lithography that can be used to synthesize multicompartmental particles. The carriers exhibited independent drug release upon exposure to the corresponding stimulus.

Original language	English
Title of host publication	21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
Publisher	Chemical and Biological Microsystems Society
Pages	358-359
Number of pages	2
ISBN (Electronic)	9780692941836
Publication status	Published - 2020
Event	21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah, United States Duration: 2017 Oct 22 → 2017 Oct 26

Publication series

Name	21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

Conference

Conference	21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
Country/Territory	United States
City	Savannah
Period	17/10/22 → 17/10/26

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF-2016R1A5A1010148, ERC).

Publisher Copyright:
© 17CBMS-0001.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer therapy
Drug release
Flow lithography
Multi-stimuli responsive drug carrier

ASJC Scopus subject areas

Chemical Engineering (miscellaneous)
Bioengineering

Cite this

Kim, H. U., Choi, D. G., Lee, H. J., Shim, M. S., & Bong, K. W. (2020). Synthesis of multi-stimuli responsive drug carriers for selective multiple drug release to tumor microenvironments. In 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 (pp. 358-359). (21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017). Chemical and Biological Microsystems Society.

Synthesis of multi-stimuli responsive drug carriers for selective multiple drug release to tumor microenvironments. / Kim, Hyeon Ung; Choi, Dae Gun; Lee, Hyun Jee et al.
21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017. Chemical and Biological Microsystems Society, 2020. p. 358-359 (21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Kim, HU, Choi, DG, Lee, HJ, Shim, MS & Bong, KW 2020, Synthesis of multi-stimuli responsive drug carriers for selective multiple drug release to tumor microenvironments. in 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017. 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017, Chemical and Biological Microsystems Society, pp. 358-359, 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017, Savannah, United States, 17/10/22.

Kim HU, Choi DG, Lee HJ, Shim MS, Bong KW. Synthesis of multi-stimuli responsive drug carriers for selective multiple drug release to tumor microenvironments. In 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017. Chemical and Biological Microsystems Society. 2020. p. 358-359. (21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017).

Kim, Hyeon Ung ; Choi, Dae Gun ; Lee, Hyun Jee et al. / Synthesis of multi-stimuli responsive drug carriers for selective multiple drug release to tumor microenvironments. 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017. Chemical and Biological Microsystems Society, 2020. pp. 358-359 (21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017).

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abstract = "Multi-stimuli responsive drug carriers have been actively researched for controlled drug release in complex tumor microenvironments. In addition to the stimuli responsive drug release, combinatorial chemotherapy is essential to increase therapeutic effects. However, previous studies have shown limitation in the synthesis of multi-compartmental drug carriers that can encapsulate multiple drugs and release each drug in a controlled manner. Here, we report multi-stimuli responsive drug carriers containing pH- and redox-sensitive multicompartments. The drug carriers were created by stop flow lithography that can be used to synthesize multicompartmental particles. The carriers exhibited independent drug release upon exposure to the corresponding stimulus.",

keywords = "Cancer therapy, Drug release, Flow lithography, Multi-stimuli responsive drug carrier",

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note = "Funding Information: This work was supported by the National Research Foundation of Korea (NRF-2016R1A5A1010148, ERC). Publisher Copyright: {\textcopyright} 17CBMS-0001.; 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 ; Conference date: 22-10-2017 Through 26-10-2017",

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AU - Kim, Hyeon Ung

AU - Choi, Dae Gun

AU - Lee, Hyun Jee

AU - Shim, Min Suk

AU - Bong, Ki Wan

N1 - Funding Information: This work was supported by the National Research Foundation of Korea (NRF-2016R1A5A1010148, ERC). Publisher Copyright: © 17CBMS-0001.

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Y1 - 2020

N2 - Multi-stimuli responsive drug carriers have been actively researched for controlled drug release in complex tumor microenvironments. In addition to the stimuli responsive drug release, combinatorial chemotherapy is essential to increase therapeutic effects. However, previous studies have shown limitation in the synthesis of multi-compartmental drug carriers that can encapsulate multiple drugs and release each drug in a controlled manner. Here, we report multi-stimuli responsive drug carriers containing pH- and redox-sensitive multicompartments. The drug carriers were created by stop flow lithography that can be used to synthesize multicompartmental particles. The carriers exhibited independent drug release upon exposure to the corresponding stimulus.

AB - Multi-stimuli responsive drug carriers have been actively researched for controlled drug release in complex tumor microenvironments. In addition to the stimuli responsive drug release, combinatorial chemotherapy is essential to increase therapeutic effects. However, previous studies have shown limitation in the synthesis of multi-compartmental drug carriers that can encapsulate multiple drugs and release each drug in a controlled manner. Here, we report multi-stimuli responsive drug carriers containing pH- and redox-sensitive multicompartments. The drug carriers were created by stop flow lithography that can be used to synthesize multicompartmental particles. The carriers exhibited independent drug release upon exposure to the corresponding stimulus.

KW - Cancer therapy

KW - Drug release

KW - Flow lithography

KW - Multi-stimuli responsive drug carrier

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M3 - Conference contribution

AN - SCOPUS:85079649059

T3 - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

SP - 358

EP - 359

BT - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

PB - Chemical and Biological Microsystems Society

T2 - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

Y2 - 22 October 2017 through 26 October 2017

ER -

Synthesis of multi-stimuli responsive drug carriers for selective multiple drug release to tumor microenvironments

Abstract

Publication series

Conference

Bibliographical note

UN SDGs

Keywords

ASJC Scopus subject areas

Other files and links

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Cite this