Synthesis of new 3-arylisoquinolinamines: Effect on topoisomerase I inhibition and cytotoxicity

Won Jea Cho; Sun Young Min; Thanh Nguyen Le; Tae Sung Kim

doi:10.1016/j.bmcl.2003.09.001

Synthesis of new 3-arylisoquinolinamines: Effect on topoisomerase I inhibition and cytotoxicity

Won Jea Cho, Sun Young Min, Thanh Nguyen Le, Tae Sung Kim

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Abstract

To investigate the structure-activity relationships of 3-arylisoquinolines, diverse substituted 3-aryisoquinolinamines were synthesized and tested in vitro antitumor activity against four tumor cell lines. Some of the compounds showed potent topoisomerase I inhibitory activity. Docking study of 7d with topoisomerase I-DNA complex was also performed.

Original language	English
Pages (from-to)	4451-4454
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	13
Issue number	24
DOIs	https://doi.org/10.1016/j.bmcl.2003.09.001
Publication status	Published - 2003 Dec 15
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2003.09.001

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title = "Synthesis of new 3-arylisoquinolinamines: Effect on topoisomerase I inhibition and cytotoxicity",

abstract = "To investigate the structure-activity relationships of 3-arylisoquinolines, diverse substituted 3-aryisoquinolinamines were synthesized and tested in vitro antitumor activity against four tumor cell lines. Some of the compounds showed potent topoisomerase I inhibitory activity. Docking study of 7d with topoisomerase I-DNA complex was also performed.",

author = "Cho, {Won Jea} and Min, {Sun Young} and Le, {Thanh Nguyen} and Kim, {Tae Sung}",

note = "Funding Information: The financial support from Korea Research Foundation (KRF-2002-015-EP0142) of Korea is appreciated. ",

year = "2003",

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doi = "10.1016/j.bmcl.2003.09.001",

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TY - JOUR

T1 - Synthesis of new 3-arylisoquinolinamines

T2 - Effect on topoisomerase I inhibition and cytotoxicity

AU - Cho, Won Jea

AU - Min, Sun Young

AU - Le, Thanh Nguyen

AU - Kim, Tae Sung

N1 - Funding Information: The financial support from Korea Research Foundation (KRF-2002-015-EP0142) of Korea is appreciated.

PY - 2003/12/15

Y1 - 2003/12/15

N2 - To investigate the structure-activity relationships of 3-arylisoquinolines, diverse substituted 3-aryisoquinolinamines were synthesized and tested in vitro antitumor activity against four tumor cell lines. Some of the compounds showed potent topoisomerase I inhibitory activity. Docking study of 7d with topoisomerase I-DNA complex was also performed.

AB - To investigate the structure-activity relationships of 3-arylisoquinolines, diverse substituted 3-aryisoquinolinamines were synthesized and tested in vitro antitumor activity against four tumor cell lines. Some of the compounds showed potent topoisomerase I inhibitory activity. Docking study of 7d with topoisomerase I-DNA complex was also performed.

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U2 - 10.1016/j.bmcl.2003.09.001

DO - 10.1016/j.bmcl.2003.09.001

M3 - Article

C2 - 14643344

AN - SCOPUS:0345358468

SN - 0960-894X

VL - 13

SP - 4451

EP - 4454

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 24

ER -

Synthesis of new 3-arylisoquinolinamines: Effect on topoisomerase I inhibition and cytotoxicity

Abstract

ASJC Scopus subject areas

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