Abstract
The development of controlled drug delivery systems is essential for side-effect-reduced therapy. Using stop flow lithography (SFL) and acid-degradable monomers, we synthesize pH-sensitive particles for targeted drug delivery. Depending on pH values, the particles exhibit differences in degradation times from minutes to hours. The degradation times of the particles can be also adjusted by controlling the synthesis conditions. To show the multi-modulated drug release, we further synthesize multi-patterned particles. The release of the beads in each compartment is programmed by designing the monomer compositions. Finally, we encapsulate proteins in the particles as a model drug and show their controlled release.
| Original language | English |
|---|---|
| Title of host publication | MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 1906-1908 |
| Number of pages | 3 |
| ISBN (Electronic) | 9780979806483 |
| Publication status | Published - 2015 |
| Event | 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 - Gyeongju, Korea, Republic of Duration: 2015 Oct 25 → 2015 Oct 29 |
Other
| Other | 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 |
|---|---|
| Country/Territory | Korea, Republic of |
| City | Gyeongju |
| Period | 15/10/25 → 15/10/29 |
Keywords
- Flow lithography
- Multi-patterned particles
- PH-sensitive drug release
ASJC Scopus subject areas
- Control and Systems Engineering