Synthesis of triarmed poly(ethylene oxide)-deoxycholic acid conjugate and its micellar characteristics

Kang Moo Huh; Kuen Yong Lee; Ick Chan Kwon; Yong Hee Kim; Chulhee Kim; Seo Young Jeong

doi:10.1021/la000978+

Synthesis of triarmed poly(ethylene oxide)-deoxycholic acid conjugate and its micellar characteristics

Kang Moo Huh, Kuen Yong Lee, Ick Chan Kwon, Yong Hee Kim, Chulhee Kim, Seo Young Jeong

KU-KIST Graduate School of Converging Science and Technology

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

The triarmed polyethylene oxide-deoxycholic acid (PEO-DC) was synthesized by the introduction of a triol group to the end of the PEO chain and by a subsequent coupling reaction with deoxycholic acid. These polymeric amphiphiles formed were stable and the spherical micelles in aqueous media have a unimodal size distribution. The triarmed PEO-DC conjugate formed micelles of smaller size at a lower critical micelle concentration than those of monosubstituted ones. This was considered to result from an increase in hydrophobicity of the triarmed conjugate.

Original language	English
Pages (from-to)	10566-10568
Number of pages	3
Journal	Langmuir
Volume	16
Issue number	26
DOIs	https://doi.org/10.1021/la000978+
Publication status	Published - 2000 Dec 26

ASJC Scopus subject areas

Materials Science(all)
Condensed Matter Physics
Surfaces and Interfaces
Spectroscopy
Electrochemistry

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10.1021/la000978+

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title = "Synthesis of triarmed poly(ethylene oxide)-deoxycholic acid conjugate and its micellar characteristics",

abstract = "The triarmed polyethylene oxide-deoxycholic acid (PEO-DC) was synthesized by the introduction of a triol group to the end of the PEO chain and by a subsequent coupling reaction with deoxycholic acid. These polymeric amphiphiles formed were stable and the spherical micelles in aqueous media have a unimodal size distribution. The triarmed PEO-DC conjugate formed micelles of smaller size at a lower critical micelle concentration than those of monosubstituted ones. This was considered to result from an increase in hydrophobicity of the triarmed conjugate.",

author = "Huh, {Kang Moo} and Lee, {Kuen Yong} and Kwon, {Ick Chan} and Kim, {Yong Hee} and Chulhee Kim and Jeong, {Seo Young}",

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T1 - Synthesis of triarmed poly(ethylene oxide)-deoxycholic acid conjugate and its micellar characteristics

AU - Huh, Kang Moo

AU - Lee, Kuen Yong

AU - Kwon, Ick Chan

AU - Kim, Yong Hee

AU - Kim, Chulhee

AU - Jeong, Seo Young

PY - 2000/12/26

Y1 - 2000/12/26

N2 - The triarmed polyethylene oxide-deoxycholic acid (PEO-DC) was synthesized by the introduction of a triol group to the end of the PEO chain and by a subsequent coupling reaction with deoxycholic acid. These polymeric amphiphiles formed were stable and the spherical micelles in aqueous media have a unimodal size distribution. The triarmed PEO-DC conjugate formed micelles of smaller size at a lower critical micelle concentration than those of monosubstituted ones. This was considered to result from an increase in hydrophobicity of the triarmed conjugate.

AB - The triarmed polyethylene oxide-deoxycholic acid (PEO-DC) was synthesized by the introduction of a triol group to the end of the PEO chain and by a subsequent coupling reaction with deoxycholic acid. These polymeric amphiphiles formed were stable and the spherical micelles in aqueous media have a unimodal size distribution. The triarmed PEO-DC conjugate formed micelles of smaller size at a lower critical micelle concentration than those of monosubstituted ones. This was considered to result from an increase in hydrophobicity of the triarmed conjugate.

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U2 - 10.1021/la000978+

DO - 10.1021/la000978+

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JO - Langmuir

JF - Langmuir

IS - 26

ER -

Synthesis of triarmed poly(ethylene oxide)-deoxycholic acid conjugate and its micellar characteristics

Abstract

ASJC Scopus subject areas

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