Synthetic bone mimetic matrix-mediated in situ bone tissue formation through host cell recruitment

Yu Ru Shih, Ameya Phadke, Tomonori Yamaguchi, Heemin Kang, Nozomu Inoue, Koichi Masuda, Shyni Varghese

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Advances in tissue engineering have offered new opportunities to restore anatomically and functionally compromised tissues. Although traditional tissue engineering approaches that utilize biomaterials and cells to create tissue constructs for implantation or biomaterials as a scaffold to deliver cells are promising, strategies that can activate endogenous cells to promote tissue repair are more clinically attractive. Here, we demonstrate that an engineered injectable matrix mimicking a calcium phosphate (CaP)-rich bone-specific microenvironment can recruit endogenous cells to form bone tissues in vivo. Comparison of matrix alone with that of bone marrow-soaked or bFGF-soaked matrix demonstrates similar extent of neo-bone formation and bridging of decorticated transverse processes in a posterolateral lumbar fusion rat model. Synthetic biomaterials that stimulate endogenous cells without the need for biologics to assist tissue repair could circumvent limitations associated with conventional tissue engineering approaches, including ex vivo cell processing and laborious efforts, thereby accelerating the translational aspects of regenerative medicine.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalActa Biomaterialia
Publication statusPublished - 2015 Jun 1
Externally publishedYes

Bibliographical note

Funding Information:
The authors gratefully acknowledge the financial support from National Institutes of Health (NIH, Grant 1 R01 AR063184-01A1 ).

Publisher Copyright:
© 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.


  • Biomimetic materials
  • Biomineralization
  • Bone grafts
  • Posterolateral fusion
  • Spine

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering
  • Molecular Biology


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