Abstract
Meta-analysis of diagnostic test accuracy studies differs from the usual meta-analysis of therapeutic/interventional studies in that, it is required to simultaneously analyze a pair of two outcome measures such as sensitivity and specificity, instead of a single outcome. Since sensitivity and specificity are generally inversely correlated and could be affected by a threshold effect, more sophisticated statistical methods are required for the meta-analysis of diagnostic test accuracy. Hierarchical models including the bivariate model and the hierarchical summary receiver operating characteristic model are increasingly being accepted as standard methods for meta-analysis of diagnostic test accuracy studies. We provide a conceptual review of statistical methods currently used and recommended for meta-analysis of diagnostic test accuracy studies. This article could serve as a methodological reference for those who perform systematic review and meta-analysis of diagnostic test accuracy studies.
Original language | English |
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Pages (from-to) | 1188-1196 |
Number of pages | 9 |
Journal | Korean journal of radiology |
Volume | 16 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2015 Nov |
Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2015 The Korean Society of Radiology.
Keywords
- Diagnostic test accuracy
- Meta-analysis
- Systematic review
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging