T-helper types 1, 2, and 3 cytokine interactions in symptomatic manic patients

Yong Ku Kim; Aye Mu Myint; Bun Hee Lee; Changsu Han; Seung Whan Lee; Brian E. Leonard; Harry W.M. Steinbusch

doi:10.1016/j.psychres.2004.08.005

T-helper types 1, 2, and 3 cytokine interactions in symptomatic manic patients

Yong Ku Kim^*, Aye Mu Myint, Bun Hee Lee, Changsu Han, Seung Whan Lee, Brian E. Leonard, Harry W.M. Steinbusch

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

92 Citations (Scopus)

Abstract

It has been reported that the balance between T-helper type 1 (Th1) cytokines and T-helper type 2 (Th2) cytokines plays a role in psychiatric disorders such as bipolar disorder. The T-helper type 3 (Th3) cytokine, which transforming growth factor beta-1 (TGF-β1), has been shown to modulate the production of Th1 and Th2 cytokines. However, the role of TGF-β1 in bipolar disorder has not yet been explored. A total of 70 manic patients with bipolar disorder and 96 normal controls was recruited. The plasma levels of IFN-γ, IL-4, and TGF-β1 were studied at the time of admission and 8 weeks after mood stabilizer treatment. The detection rate and plasma concentrations of IFN-γ and IL-4 and the IFN-γ/TGF-β1 and IL-4/TGF-β1 ratios were significantly higher in patients than in controls, while the TGF-β1 level was significantly lower. The TGF-β1 level increased significantly after treatment and the IFN-γ/TGF-β1 and IL-4/TGF-β1 ratios returned to control values. TGF-β1 may play a role in the pathophysiology of bipolar disorder through the action of TGF-β1 in modulating the IL-4/TGF-β1 ratio.

Original language	English
Pages (from-to)	267-272
Number of pages	6
Journal	Psychiatry Research
Volume	129
Issue number	3
DOIs	https://doi.org/10.1016/j.psychres.2004.08.005
Publication status	Published - 2004 Dec 30
Externally published	Yes

Bibliographical note

Funding Information:
Dr. Yong-Ku Kim was supported by the Brain Korea 21 Project of the Ministry of Education and Human Resources Development, Republic of Korea.

Keywords

Bipolar disorder
Cytokine
Interferon
Interleukin
Lithium
TGF

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.psychres.2004.08.005

Cite this

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title = "T-helper types 1, 2, and 3 cytokine interactions in symptomatic manic patients",

abstract = "It has been reported that the balance between T-helper type 1 (Th1) cytokines and T-helper type 2 (Th2) cytokines plays a role in psychiatric disorders such as bipolar disorder. The T-helper type 3 (Th3) cytokine, which transforming growth factor beta-1 (TGF-β1), has been shown to modulate the production of Th1 and Th2 cytokines. However, the role of TGF-β1 in bipolar disorder has not yet been explored. A total of 70 manic patients with bipolar disorder and 96 normal controls was recruited. The plasma levels of IFN-γ, IL-4, and TGF-β1 were studied at the time of admission and 8 weeks after mood stabilizer treatment. The detection rate and plasma concentrations of IFN-γ and IL-4 and the IFN-γ/TGF-β1 and IL-4/TGF-β1 ratios were significantly higher in patients than in controls, while the TGF-β1 level was significantly lower. The TGF-β1 level increased significantly after treatment and the IFN-γ/TGF-β1 and IL-4/TGF-β1 ratios returned to control values. TGF-β1 may play a role in the pathophysiology of bipolar disorder through the action of TGF-β1 in modulating the IL-4/TGF-β1 ratio.",

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author = "Kim, \{Yong Ku\} and Myint, \{Aye Mu\} and Lee, \{Bun Hee\} and Changsu Han and Lee, \{Seung Whan\} and Leonard, \{Brian E.\} and Steinbusch, \{Harry W.M.\}",

note = "Funding Information: Dr. Yong-Ku Kim was supported by the Brain Korea 21 Project of the Ministry of Education and Human Resources Development, Republic of Korea.",

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doi = "10.1016/j.psychres.2004.08.005",

language = "English",

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AU - Kim, Yong Ku

AU - Myint, Aye Mu

AU - Lee, Bun Hee

AU - Han, Changsu

AU - Lee, Seung Whan

AU - Leonard, Brian E.

AU - Steinbusch, Harry W.M.

N1 - Funding Information: Dr. Yong-Ku Kim was supported by the Brain Korea 21 Project of the Ministry of Education and Human Resources Development, Republic of Korea.

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N2 - It has been reported that the balance between T-helper type 1 (Th1) cytokines and T-helper type 2 (Th2) cytokines plays a role in psychiatric disorders such as bipolar disorder. The T-helper type 3 (Th3) cytokine, which transforming growth factor beta-1 (TGF-β1), has been shown to modulate the production of Th1 and Th2 cytokines. However, the role of TGF-β1 in bipolar disorder has not yet been explored. A total of 70 manic patients with bipolar disorder and 96 normal controls was recruited. The plasma levels of IFN-γ, IL-4, and TGF-β1 were studied at the time of admission and 8 weeks after mood stabilizer treatment. The detection rate and plasma concentrations of IFN-γ and IL-4 and the IFN-γ/TGF-β1 and IL-4/TGF-β1 ratios were significantly higher in patients than in controls, while the TGF-β1 level was significantly lower. The TGF-β1 level increased significantly after treatment and the IFN-γ/TGF-β1 and IL-4/TGF-β1 ratios returned to control values. TGF-β1 may play a role in the pathophysiology of bipolar disorder through the action of TGF-β1 in modulating the IL-4/TGF-β1 ratio.

AB - It has been reported that the balance between T-helper type 1 (Th1) cytokines and T-helper type 2 (Th2) cytokines plays a role in psychiatric disorders such as bipolar disorder. The T-helper type 3 (Th3) cytokine, which transforming growth factor beta-1 (TGF-β1), has been shown to modulate the production of Th1 and Th2 cytokines. However, the role of TGF-β1 in bipolar disorder has not yet been explored. A total of 70 manic patients with bipolar disorder and 96 normal controls was recruited. The plasma levels of IFN-γ, IL-4, and TGF-β1 were studied at the time of admission and 8 weeks after mood stabilizer treatment. The detection rate and plasma concentrations of IFN-γ and IL-4 and the IFN-γ/TGF-β1 and IL-4/TGF-β1 ratios were significantly higher in patients than in controls, while the TGF-β1 level was significantly lower. The TGF-β1 level increased significantly after treatment and the IFN-γ/TGF-β1 and IL-4/TGF-β1 ratios returned to control values. TGF-β1 may play a role in the pathophysiology of bipolar disorder through the action of TGF-β1 in modulating the IL-4/TGF-β1 ratio.

KW - Bipolar disorder

KW - Cytokine

KW - Interferon

KW - Interleukin

KW - Lithium

KW - TGF

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JF - Psychiatry Research

IS - 3

ER -

T-helper types 1, 2, and 3 cytokine interactions in symptomatic manic patients

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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