Abstract
Antibody Fc region, a recruiter and a frontline commander in the combat against cancer and infectious pathogens, mediates potent immune effector functions by engaging Fc receptors and serum complement proteins. Recent studies indicate that the Fc region is particularly amenable to modifications that enhance potency and serum stability through amino acid substitution and glycan modification. In order to modulate the interaction of the Fc domain with Fc-binding ligands (FcγRs, C1q, and FcRn), various engineering strategies have been employed; these studies are discussed in this review.
Original language | English |
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Pages (from-to) | 625-636 |
Number of pages | 12 |
Journal | Biotechnology and Bioprocess Engineering |
Volume | 18 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2013 Jul |
Externally published | Yes |
Keywords
- Fc engineering
- antibody engineering
- effector functions
- therapeutic antibody
ASJC Scopus subject areas
- Biotechnology
- Bioengineering
- Applied Microbiology and Biotechnology
- Biomedical Engineering