Tamalin Function Is Required for the Survival of Neurons and Oligodendrocytes in the CNS

Yongbo Seo, Seojung Mo, Suhyun Kim, Hyun Kim, Hae Chul Park

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1 Citation (Scopus)


Tamalin is a post-synaptic scaffolding protein that interacts with group 1 metabotropic glutamate receptors (mGluRs) and several other proteins involved in protein trafficking and cytoskeletal events, including neuronal growth and actin reorganization. It plays an important role in synaptic plasticity in vitro by controlling the ligand-dependent trafficking of group 1 mGluRs. Abnormal regulation of mGluRs in the central nervous system (CNS) is associated with glutamate-mediated neurodegenerative disorders. However, the pathological consequences of tamalin deficiency in the CNS are unclear. In this study, tamalin knockout (KO) zebrafish and mice exhibited neurodegeneration along with oligodendrocyte degeneration in the post-embryonic CNS to adulthood without any developmental defects, thus suggesting the function of tamalin is more important in the postnatal stage to adulthood than that in CNS development. Interestingly, hypomyelination was independent of axonal defects in the CNS of tamalin knockout zebrafish and mice. In addition, the loss of Arf6, a downstream signal of tamalin scaffolding protein, synergistically induced neurodegeneration in tamalin KO zebrafish even in the developing CNS. Furthermore, tamalin KO zebrafish displayed increased mGluR5 expression. Taken together, tamalin played an important role in neuronal and oligodendrocyte survival and myelination through the regulation of mGluR5 in the CNS.

Original languageEnglish
Article number13395
JournalInternational journal of molecular sciences
Issue number21
Publication statusPublished - 2022 Nov

Bibliographical note

Funding Information:
This research was supported by the Bio and Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MSIT) (2021M3H9A1097594) and by the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (NRF 2020M3E5D9080794).

Publisher Copyright:
© 2022 by the authors.


  • arf6
  • mGluR5
  • mice
  • neurodegeneration
  • oligodendrocytes
  • tamalin
  • zebrafish

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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