TY - JOUR
T1 - Targeted delivery of low molecular drugs using chitosan and its derivatives
AU - Park, Jae Hyung
AU - Saravanakumar, Gurusamy
AU - Kim, Kwangmeyung
AU - Kwon, Ick Chan
N1 - Funding Information:
This research was financially supported by the BioImaging Research Center at GIST, the Seoul R&DB program , the Real-Time Molecular Imaging Project , and Ministry of Health, Welfare and Family Affairs ( A062254 ).
Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.
PY - 2010/1/31
Y1 - 2010/1/31
N2 - Chitosan has prompted the continuous impetus for the development of safe and effective drug delivery systems because of its unique physicochemical and biological characteristics. The primary hydroxyl and amine groups located on the backbone of chitosan allow for chemical modification to control its physical properties. When the hydrophobic moiety is conjugated to a chitosan molecule, the resulting amphiphile may form self-assembled nanoparticles that can encapsulate a quantity of drugs and deliver them to a specific site of action. Chemical attachment of the drug to the chitosan throughout the functional linker may produce useful prodrugs, exhibiting the appropriate biological activity at the target site. Mucoadhesive and absorption enhancement properties of chitosan increase the in vivo residence time of the dosage form in the gastrointestinal tract and improve the bioavailability of various drugs. The main objective of this review is to provide an insight into various target-specific carriers, based on chitosan and its derivatives, towards low molecular weight drug delivery. The first part of the review is concerned with the organ-specific delivery of low molecular drugs using chitosan and its derivatives. The subsequent section considers the recent developments of drug delivery carriers for cancer therapy with special focus on various targeting strategies.
AB - Chitosan has prompted the continuous impetus for the development of safe and effective drug delivery systems because of its unique physicochemical and biological characteristics. The primary hydroxyl and amine groups located on the backbone of chitosan allow for chemical modification to control its physical properties. When the hydrophobic moiety is conjugated to a chitosan molecule, the resulting amphiphile may form self-assembled nanoparticles that can encapsulate a quantity of drugs and deliver them to a specific site of action. Chemical attachment of the drug to the chitosan throughout the functional linker may produce useful prodrugs, exhibiting the appropriate biological activity at the target site. Mucoadhesive and absorption enhancement properties of chitosan increase the in vivo residence time of the dosage form in the gastrointestinal tract and improve the bioavailability of various drugs. The main objective of this review is to provide an insight into various target-specific carriers, based on chitosan and its derivatives, towards low molecular weight drug delivery. The first part of the review is concerned with the organ-specific delivery of low molecular drugs using chitosan and its derivatives. The subsequent section considers the recent developments of drug delivery carriers for cancer therapy with special focus on various targeting strategies.
KW - Chitosan
KW - Low molecular drugs
KW - Targeted delivery
UR - http://www.scopus.com/inward/record.url?scp=75149147998&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=75149147998&partnerID=8YFLogxK
U2 - 10.1016/j.addr.2009.10.003
DO - 10.1016/j.addr.2009.10.003
M3 - Review article
C2 - 19874862
AN - SCOPUS:75149147998
SN - 0169-409X
VL - 62
SP - 28
EP - 41
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
IS - 1
ER -