Targeting of marrow-derived astrocytes to the ischemic brain

Martin A. Eglitis, Debbie Dawson, Kun Woo Park, M. Maral Mouradian

Research output: Contribution to journalArticlepeer-review

134 Citations (Scopus)


BONE marrow progenitor cells have been shown to contribute to a small proportion of cells in nonhematopoietic tissues including the brain. In the acute unilateral middle cerebral artery occlusion model in spontaneously hypertensive rats following male-to-female bone marrow transplantation, we present data suggesting that 55% more marrow-derived cells, in general, and 161% more GFAP-positive astrocytes, in particular, migrate preferentially to the ischemic cortex than to the contralateral non-ischemic hemisphere. In addition to their biological significance, our findings could have therapeutic implications. Marrow-derived progenitor cells could potentially be used as vehicles for ex vivo gene transfer to the brain.

Original languageEnglish
Pages (from-to)1289-1292
Number of pages4
Issue number6
Publication statusPublished - 1999 Apr 26
Externally publishedYes


  • Astrocyte
  • Bone marrow
  • Brain
  • Fluorescent in situ hybridization
  • Ischemia
  • Transplantation

ASJC Scopus subject areas

  • General Neuroscience


Dive into the research topics of 'Targeting of marrow-derived astrocytes to the ischemic brain'. Together they form a unique fingerprint.

Cite this