Taste Receptors beyond Taste Buds

Su Young Ki, Yong Taek Jeong

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)

Abstract

Taste receptors are responsible for detecting their ligands not only in taste receptor cells (TRCs) but also in non-gustatory organs. For several decades, many research groups have accumulated evidence for such "ectopic" expression of taste receptors. More recently, some of the physiologic functions (apart from taste) of these ectopic taste receptors have been identified. Here, we summarize our current understanding of these ectopic taste receptors across multiple organs. With a particular focus on the specialized epithelial cells called tuft cells, which are now considered siblings of type II TRCs, we divide the ectopic expression of taste receptors into two categories: taste receptors in TRC-like cells outside taste buds and taste receptors with surprising ectopic expression in completely different cell types.

Original languageEnglish
JournalInternational journal of molecular sciences
Volume23
Issue number17
DOIs
Publication statusPublished - 2022 Aug 26

Keywords

  • G protein-coupled receptors
  • ectopic expression
  • taste
  • taste receptors
  • tuft cells

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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