Tau positron emission tomography using [18F]THK5351 and cerebral glucose hypometabolism in Alzheimer's disease

Jae Myeong Kang, Sang Yoon Lee, Seongho Seo, Hye Jin Jeong, Sung Ho Woo, Hyon Lee, Yeong Bae Lee, Byeong Kil Yeon, Dong Hoon Shin, Kee Hyung Park, Hyejin Kang, Nobuyuki Okamura, Shozo Furumoto, Kazuhiko Yanai, Victor L. Villemagne, Joon Kyung Seong, Duk L. Na, Tatsuo Ido, Jaelim Cho, Kyoung Min LeeYoung Noh

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)


This study aims to evaluate the clinical validity of [18F]THK5351 positron emission tomography (PET) for the assessment of disease progression and symptoms in Alzheimer's disease (AD). Fifty-one patients with AD dementia, 30 patients with amnestic mild cognitive impairment (aMCI), and 43 controls with normal cognition (NC) were included. All subjects underwent [18F]THK5351 PET, 3.0-T magnetic resonance imaging, and detailed neuropsychological tests. Regions of interest and voxel-based statistical analyses were performed. In patients with AD dementia, [18F]THK5351 retention was greater in most association cortices as well as the limbic area compared to NC or aMCI participants. Patients with aMCI also showed higher THK5351 retention in those areas compared to NC. [18F]THK5351 retention significantly correlated with neuropsychological test results. Negative correlations between [18F]THK5351 and [18F] fluorodeoxyglucose were observed in AD dementia and aMCI groups. Mirror images of [18F]THK5351 retention and glucose hypometabolism in [18F] fluorodeoxyglucose were noticeable in the focal variants of AD. [18F]THK5351 PET reflects disease severity and symptoms in AD. Our results suggest [18F]THK5351 is reflective of tau-related AD pathology.

Original languageEnglish
Pages (from-to)210-219
Number of pages10
JournalNeurobiology of Aging
Publication statusPublished - 2017 Nov

Bibliographical note

Funding Information:
This study was supported by a grant from the Korea Healthcare Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare of the Republic of Korea (grant No: HI14C1135).

Publisher Copyright:
© 2017 Elsevier Inc.


  • Alzheimer's disease
  • Neurofibrillary tangles
  • Positron emission tomography
  • THK
  • Tau

ASJC Scopus subject areas

  • General Neuroscience
  • Ageing
  • Developmental Biology
  • Clinical Neurology
  • Geriatrics and Gerontology


Dive into the research topics of 'Tau positron emission tomography using [18F]THK5351 and cerebral glucose hypometabolism in Alzheimer's disease'. Together they form a unique fingerprint.

Cite this