Telomere integrated scoring system of myelodysplastic syndrome

Hee Sue Park, Kyongok Im, Dong Yeop Shin, Sung Soo Yoon, Sunghoon Kwon, Suhng Wook Kim, Dong Soon Lee

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Recently, multigene target sequencing is widely performed for the purpose of prognostic prediction and application of targeted therapy. Here, we proposed a new scoring system that encompasses gene variations, telomere length, and Revised International Prognostic Scoring System (IPSS-R) together in Asian myelodysplastic syndrome. Methods: We developed a new scoring model of these variables: age ≥ 65 years + IPSS-R score + ASXL1 mutation + TP53 mutation + Telomere length (<5.37). According to this new scoring system, patients were divided into four groups: very good score cutoff (≤3.0), good (3.0–4.5), poor (4.5–7.0), and very poor (>7.0). Results: The median OS was 170.1, 100.4, 46.0, and 12.0 months for very good, good, poor, and very poor, retrospectively (p < 0.001). Meanwhile, according to the conventional IPSS-R scoring system, the median OS was 141.3, 50.2, 93.0, 36.0, and 16.2 months for very low, low, intermediate, high, and very high, retrospectively (p < 0.001). Conclusions: The newly developed model incorporating molecular variations and TL yielded more clear separations of the survival curves. By adding the presence of gene mutation and telomere length to the existing IPSS-R, its predictive ability can be further improved in myelodysplastic syndrome.

Original languageEnglish
Article numbere24839
JournalJournal of Clinical Laboratory Analysis
Volume37
Issue number3
DOIs
Publication statusPublished - 2023 Feb

Bibliographical note

Funding Information:
This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Korean government (MSIT) (NRF‐2017R1A2A1A17069780). This work was supported by the Ministry of Science and ICT(MSIT) of the Republic of Korea and the National Research Foundation of Korea (NRF‐2020R1A3B3079653).

Funding Information:
This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Korean government (MSIT) (NRF-2017R1A2A1A17069780). This work was supported by the Ministry of Science and ICT(MSIT) of the Republic of Korea and the National Research Foundation of Korea (NRF-2020R1A3B3079653).

Publisher Copyright:
© 2023 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC.

Keywords

  • Revised International Prognostic Scoring System
  • myelodysplastic syndrome
  • targeted capture sequencing
  • telomere length

ASJC Scopus subject areas

  • Immunology and Allergy
  • Hematology
  • Public Health, Environmental and Occupational Health
  • Clinical Biochemistry
  • Medical Laboratory Technology
  • Biochemistry, medical
  • Microbiology (medical)

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