Telomere length shortening of peripheral blood mononuclear cells in solid-cancer patients undergoing standard-dose chemotherapy might be correlated with good treatment response and neutropenia severity

So Young Yoon; Hwa Jung Sung; Kyong Hwa Park; In Keun Choi; Seok Jin Kim; Sang Cheul Oh; Jae Hong Seo; Chul Won Choi; Byung Soo Kim; Sang Won Shin; Yeul Hong Kim; Jun Suk Kim

doi:10.1159/000101558

Telomere length shortening of peripheral blood mononuclear cells in solid-cancer patients undergoing standard-dose chemotherapy might be correlated with good treatment response and neutropenia severity

So Young Yoon, Hwa Jung Sung, Kyong Hwa Park, In Keun Choi, Seok Jin Kim, Sang Cheul Oh, Jae Hong Seo, Chul Won Choi, Byung Soo Kim, Sang Won Shin, Yeul Hong Kim, Jun Suk Kim

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

This study evaluated the telomere length changes (ΔTL) of peripheral blood mononuclear cells before and after repetitive standard-dose nonmyeloablative chemotherapy and the association of ΔTL with treatment response and myelosuppression severity. TL was measured with Southern blot analysis in 32 solid-cancer patients without bone marrow metastasis. The mean TL before chemotherapy (t0 TL) and after the 2nd (t1 TL), 4th (t2 TL) and 6th cycle (t3 TL) was 8.49, 8.33, 8.08 and 8.10 kb, respectively. TL became significantly decreased after 4 (p = 0.005) and 6 (p = 0.026) cycles of chemotherapy. The mean value of ΔTL before and after completion of chemotherapy (t0 TL - t3 TL) was 0.46 kb. ΔTL has a significant correlation with good treatment response (r = 0.448, p = 0.005) and the frequency of severe neutropenia (r = 0.417, p < 0.05). Consequently, TL of peripheral blood mononuclear cells was decreased by the repetitive nonmyeloablative standard-dose chemotherapy in solid-cancer patients without bone marrow metastasis, and ΔTL was associated with good treatment response and neutropenia severity.

Original language	English
Pages (from-to)	30-37
Number of pages	8
Journal	Acta Haematologica
Volume	118
Issue number	1
DOIs	https://doi.org/10.1159/000101558
Publication status	Published - 2007 Jun

Keywords

Cancer chemotherapy, nonmyeloablative
Neutropenia
Telomere length

ASJC Scopus subject areas

Hematology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000101558

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Yoon, S. Y., Sung, H. J., Park, K. H., Choi, I. K., Kim, S. J., Oh, S. C., Seo, J. H., Choi, C. W., Kim, B. S., Shin, S. W., Kim, Y. H., & Kim, J. S. (2007). Telomere length shortening of peripheral blood mononuclear cells in solid-cancer patients undergoing standard-dose chemotherapy might be correlated with good treatment response and neutropenia severity. Acta Haematologica, 118(1), 30-37. https://doi.org/10.1159/000101558

Telomere length shortening of peripheral blood mononuclear cells in solid-cancer patients undergoing standard-dose chemotherapy might be correlated with good treatment response and neutropenia severity. / Yoon, So Young; Sung, Hwa Jung; Park, Kyong Hwa et al.
In: Acta Haematologica, Vol. 118, No. 1, 06.2007, p. 30-37.

Research output: Contribution to journal › Article › peer-review

Yoon, SY, Sung, HJ, Park, KH, Choi, IK, Kim, SJ, Oh, SC, Seo, JH, Choi, CW, Kim, BS, Shin, SW, Kim, YH & Kim, JS 2007, 'Telomere length shortening of peripheral blood mononuclear cells in solid-cancer patients undergoing standard-dose chemotherapy might be correlated with good treatment response and neutropenia severity', Acta Haematologica, vol. 118, no. 1, pp. 30-37. https://doi.org/10.1159/000101558

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abstract = "This study evaluated the telomere length changes (ΔTL) of peripheral blood mononuclear cells before and after repetitive standard-dose nonmyeloablative chemotherapy and the association of ΔTL with treatment response and myelosuppression severity. TL was measured with Southern blot analysis in 32 solid-cancer patients without bone marrow metastasis. The mean TL before chemotherapy (t0 TL) and after the 2nd (t1 TL), 4th (t2 TL) and 6th cycle (t3 TL) was 8.49, 8.33, 8.08 and 8.10 kb, respectively. TL became significantly decreased after 4 (p = 0.005) and 6 (p = 0.026) cycles of chemotherapy. The mean value of ΔTL before and after completion of chemotherapy (t0 TL - t3 TL) was 0.46 kb. ΔTL has a significant correlation with good treatment response (r = 0.448, p = 0.005) and the frequency of severe neutropenia (r = 0.417, p < 0.05). Consequently, TL of peripheral blood mononuclear cells was decreased by the repetitive nonmyeloablative standard-dose chemotherapy in solid-cancer patients without bone marrow metastasis, and ΔTL was associated with good treatment response and neutropenia severity.",

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AU - Yoon, So Young

AU - Sung, Hwa Jung

AU - Park, Kyong Hwa

AU - Choi, In Keun

AU - Kim, Seok Jin

AU - Oh, Sang Cheul

AU - Seo, Jae Hong

AU - Choi, Chul Won

AU - Kim, Byung Soo

AU - Shin, Sang Won

AU - Kim, Yeul Hong

AU - Kim, Jun Suk

PY - 2007/6

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N2 - This study evaluated the telomere length changes (ΔTL) of peripheral blood mononuclear cells before and after repetitive standard-dose nonmyeloablative chemotherapy and the association of ΔTL with treatment response and myelosuppression severity. TL was measured with Southern blot analysis in 32 solid-cancer patients without bone marrow metastasis. The mean TL before chemotherapy (t0 TL) and after the 2nd (t1 TL), 4th (t2 TL) and 6th cycle (t3 TL) was 8.49, 8.33, 8.08 and 8.10 kb, respectively. TL became significantly decreased after 4 (p = 0.005) and 6 (p = 0.026) cycles of chemotherapy. The mean value of ΔTL before and after completion of chemotherapy (t0 TL - t3 TL) was 0.46 kb. ΔTL has a significant correlation with good treatment response (r = 0.448, p = 0.005) and the frequency of severe neutropenia (r = 0.417, p < 0.05). Consequently, TL of peripheral blood mononuclear cells was decreased by the repetitive nonmyeloablative standard-dose chemotherapy in solid-cancer patients without bone marrow metastasis, and ΔTL was associated with good treatment response and neutropenia severity.

AB - This study evaluated the telomere length changes (ΔTL) of peripheral blood mononuclear cells before and after repetitive standard-dose nonmyeloablative chemotherapy and the association of ΔTL with treatment response and myelosuppression severity. TL was measured with Southern blot analysis in 32 solid-cancer patients without bone marrow metastasis. The mean TL before chemotherapy (t0 TL) and after the 2nd (t1 TL), 4th (t2 TL) and 6th cycle (t3 TL) was 8.49, 8.33, 8.08 and 8.10 kb, respectively. TL became significantly decreased after 4 (p = 0.005) and 6 (p = 0.026) cycles of chemotherapy. The mean value of ΔTL before and after completion of chemotherapy (t0 TL - t3 TL) was 0.46 kb. ΔTL has a significant correlation with good treatment response (r = 0.448, p = 0.005) and the frequency of severe neutropenia (r = 0.417, p < 0.05). Consequently, TL of peripheral blood mononuclear cells was decreased by the repetitive nonmyeloablative standard-dose chemotherapy in solid-cancer patients without bone marrow metastasis, and ΔTL was associated with good treatment response and neutropenia severity.

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KW - Neutropenia

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Telomere length shortening of peripheral blood mononuclear cells in solid-cancer patients undergoing standard-dose chemotherapy might be correlated with good treatment response and neutropenia severity

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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