Abstract
Background/Aims: This study was performed to evaluate trends in antibiotic usage at a tertiary care hospital in Korea. Methods: This study collated antibiotic prescription data and total patient days for inpatients at a tertiary care hospital in Korea between 2004 and 2013. The consumption of each class of antibiotic was converted to def ined daily dose (DDD)/1,000 patient-days. We def ined 3rd generation cephalosporins, 4th generation cephalosporins, β-lactam/β-lactamase inhibitors, and fluoroquinolones as broad-spectrum antibiotics; carbapenems, tigecycline, glycopeptides, oxazo-lidinone, and polymyxin were defined as antibiotics against multidrug-resistant (MDR) pathogens. Other antibiotic classes were defined as nonbroad-spectrum antibiotics. Results: Mean antibiotic consumption was 920.69 DDD/1,000 patient-days. The proportions of broad-spectrum antibiotics, antibiotics against MDR pathogens, and nonbroad-spectrum antibiotics were 41.8% (384.48/920.69), 3.5% (32.24/920.69), and 54.7% (503.97/920.69), respectively. Consumption of broad-spectrum antibiotics (coefficient for time 0.141; p = 0.049) and antibiotics against MDR pathogens (coefficient for time 0.185; p < 0.001) showed a significant increasing trend over the study period. Nonbroad-spectrum antibiotic consumption showed a signif icant decreasing trend over the study period (coefficient for time –2.601; p < 0.001). Conclusions: Over the 10-year period, a stepwise increase in the consumption of broad-spectrum antibiotics and antibiotics against MDR pathogens was observed at a tertiary care hospital in Korea. Conversely, during the same period, non-broad-spectrum antibiotic consumption showed a significant decreasing trend.
Original language | English |
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Pages (from-to) | 703-713 |
Number of pages | 11 |
Journal | Korean Journal of Internal Medicine |
Volume | 35 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2020 May |
Bibliographical note
Publisher Copyright:© 2020 The Korean Association of Internal Medicine.
Keywords
- Anti-bacterial agents
- Hospitals
- Korea
ASJC Scopus subject areas
- Internal Medicine