Ten-year trends in antibiotic usage at a tertiary care hospital in Korea, 2004 to 2013

Bongyoung Kim, Hyeonjun Hwang, Jieun Kim, Myoung Jae Lee, Hyunjoo Pai

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13 Citations (Scopus)


Background/Aims: This study was performed to evaluate trends in antibiotic usage at a tertiary care hospital in Korea. Methods: This study collated antibiotic prescription data and total patient days for inpatients at a tertiary care hospital in Korea between 2004 and 2013. The consumption of each class of antibiotic was converted to def ined daily dose (DDD)/1,000 patient-days. We def ined 3rd generation cephalosporins, 4th generation cephalosporins, β-lactam/β-lactamase inhibitors, and fluoroquinolones as broad-spectrum antibiotics; carbapenems, tigecycline, glycopeptides, oxazo-lidinone, and polymyxin were defined as antibiotics against multidrug-resistant (MDR) pathogens. Other antibiotic classes were defined as nonbroad-spectrum antibiotics. Results: Mean antibiotic consumption was 920.69 DDD/1,000 patient-days. The proportions of broad-spectrum antibiotics, antibiotics against MDR pathogens, and nonbroad-spectrum antibiotics were 41.8% (384.48/920.69), 3.5% (32.24/920.69), and 54.7% (503.97/920.69), respectively. Consumption of broad-spectrum antibiotics (coefficient for time 0.141; p = 0.049) and antibiotics against MDR pathogens (coefficient for time 0.185; p < 0.001) showed a significant increasing trend over the study period. Nonbroad-spectrum antibiotic consumption showed a signif icant decreasing trend over the study period (coefficient for time –2.601; p < 0.001). Conclusions: Over the 10-year period, a stepwise increase in the consumption of broad-spectrum antibiotics and antibiotics against MDR pathogens was observed at a tertiary care hospital in Korea. Conversely, during the same period, non-broad-spectrum antibiotic consumption showed a significant decreasing trend.

Original languageEnglish
Pages (from-to)703-713
Number of pages11
JournalKorean Journal of Internal Medicine
Issue number3
Publication statusPublished - 2020 May

Bibliographical note

Publisher Copyright:
© 2020 The Korean Association of Internal Medicine.


  • Anti-bacterial agents
  • Hospitals
  • Korea

ASJC Scopus subject areas

  • Internal Medicine


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