Abstract
TGF-β-induced gene-h3 (βig-h3) is an adhesive molecule that interacts with integrins. Because TGF-β plays an important role in diabetic complications and βig-h3 serves as a cell substrate, we hypothesized that diabetic conditions might increase βig-h3 synthesis in vascular smooth muscle cells (VSMCs), which may subsequently contribute to the pathogenesis of diabetic angiopathy. The concentrations of βig-h3 and TGF-β were measured in conditioned media using an enzyme-linked immunosorbent assay. An immunohistochemical study showed that βig-h3 was expressed in the VSMCs and the matrix of rat aortas. TGF-β stimulated βig-h3 production, and high glucose induced βig-h3 as well as TGF-β production in the VSMCs. The high glucose-induced βig-h3 expression was almost entirely blocked by an anti-TGF-β antibody. βig-h3 protein mediated the adhesion, spreading, migration, and proliferation of rat VSMCs. These results suggest that the high glucose-induced βig-h3 in VSMCs regulates VSMC functions and may play an important role in diabetic angiopathy.
| Original language | English |
|---|---|
| Pages (from-to) | 774-782 |
| Number of pages | 9 |
| Journal | Journal of cellular biochemistry |
| Volume | 88 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2003 Mar 1 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Diabetic angiopathy
- High glucose
- TGF-β
- Vascular smooth muscle cells
- βig-h3
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology
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