Abstract
Collagen-induced arthritis (CIA) is mediated by self-re-active CD4+ T cells that produce inflammatory cytokines. TGF-β2-treated tolerogenic antigen-presenting cells (Tol-APCs) are known to induce tolerance in various autoimmune diseases. In this study, we investigated whether collagen-specific Tol-APCs could induce suppression of CIA. We observed that Tol-APCs could suppress the development and se-verity of CIA and delay the onset of CIA. Treatment of Tol-APCs reduced the number of IFN-γ- and IL-17-producing CD4+ T cells and increased IL-4- and IL-5-producing CD4+ T cells upon collagen antigen stimulation in vitro. The suppression of CIA conferred by Tol-APCs correlated with their ability to selectively induce IL-10 production. We also observed that treatment of Tol-APCs inhibited not only cellular immune responses but also humoral immune responses in the process of CIA. Our results suggest that in vitro-generated Tol-APCs have potential therapeutic value for the treatment of rheumatoid arthritis as well as other autoimmune diseases.
Original language | English |
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Pages (from-to) | 187-194 |
Number of pages | 8 |
Journal | Experimental and Molecular Medicine |
Volume | 42 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2010 Mar 31 |
Keywords
- Antigen-presenting cells
- Arthritis
- Autoimmune diseases
- Experimental
- Immune tolerance
- Th1 cells
- Th2 cells
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Clinical Biochemistry