TGFBIp/βig-h3 protein: A versatile matrix molecule induced by TGF-β

Narendra Thapa, Byung Heon Lee, In San Kim

Research output: Contribution to journalReview articlepeer-review

166 Citations (Scopus)


TGFBIp/βig-h3 protein is an extracellular matrix molecule initially cloned from human adenocarcinoma cells treated with TGF-β. Its precise function remains obscure but a number of studies have demonstrated it to be an intriguingly versatile molecule role in a wide range of physiological and pathological conditions. To date, the most extensively studied and reported action of TGFBIp/βig-h3 protein is in corneal dystrophy and several excellent reviews are available on this. Work from various laboratories on this molecule has compiled a tremendous amount of information over the past decade and a half. Here we review the current understanding on TGFBIp/βig-h3 protein and its functions in morphogenesis, extracellular matrix interactions, adhesion/migration, corneal dystrophy, tumorigenesis, angiogenesis, nephropathies, osteogenesis, wound healing and inflammation.

Original languageEnglish
Pages (from-to)2183-2194
Number of pages12
JournalInternational Journal of Biochemistry and Cell Biology
Issue number12
Publication statusPublished - 2007
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by Brain Korea 21 programs and Regional Research Center. The authors apologize for omission of some references due to space limitations.

Copyright 2009 Elsevier B.V., All rights reserved.


  • Angiogenesis
  • Cell adhesion
  • FAS1 domain
  • Inflammation
  • Integrin
  • Nephropathy
  • Osteogenesis
  • Tumorigenesis
  • Wound healing
  • βig-h3

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology


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