Adjusting the mechanical strength of a biomaterial to suit its intended application is very important for realizing beneficial outcomes. Microfluidic spinning fiber have been attracting attention recently due to their various advantages, but their mechanical strength has unfortunately not been a subject of concentrated research, and this lack of research has severely limited their applications. In the current work, we showed the mechanical properties of microfibers can be tuned easily and provided a mathematical explanation for how the microfluidic spinning method intrinsically controls the mechanical properties of a microfluidic spinning fiber. But we were also able to adjust the mechanical properties of such fibers in various other ways, including by using biomolecules to coat the fiber or mixing the biomolecules with the primary component of the fiber and by using a customized twisting machine to change the number of single microfiber strands forming the fiber. We used the bundle fiber as an ophthalmology suture that resulted in a porcine eye with a smoother post-operative surface than did a nylon suture. The results showed the possibility that the proposed method can solve current problems of the microfibers in practical applications, and can thus extend the range of applications of these microfibers.
Bibliographical noteFunding Information:
This work was supported by the KU-KIST Graduate School of Converging Science and Technology Program, and by Global Ph.D. Fellowship Program of National Research Foundation, Republic of Korea [2015H1A2A1033269]. Dr. Cho Hay Mun first suggested the core idea of this experiment. Geon Hui Lee and Seong-Ho Go of Korea University gave us a lot of help in constructing the CTM. Porcine hdECM and the idea of mixing hdECM with PLCL solution were suggested by Tae Hee Kim of Korea University. We gratefully acknowledge the late Professor Sang-Hoon Lee for organizing the experiments of all the sessions.
© 2017 The Author(s).
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