Abstract
The development of the 2-(4-trifluoromethylphenylsulfonyl)ethoxycarbonyl (Tsc) function, a novel base-sensitive amino-protecting group, and its application to the preparation of DNA-binding polyamides are described. Pyrrole-imidazole polyamides were synthesized by an efficient solid-phase method under conditions compatible with Fmoc chemistry using two Tsc-protected amino acids, Tsc-Py-OH 1a and Tsc-Im-OH 1b.
Original language | English |
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Pages (from-to) | 1607-1610 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 44 |
Issue number | 8 |
DOIs | |
Publication status | Published - 2003 Feb 17 |
Bibliographical note
Funding Information:This work was financially supported by the Basic Research (Grant No. 981-0302-009-2) and CRM programs from KOSEF. Fellowship support from the BK21 program (J.S.C., Y.L., E.K.) is gratefully acknowledged.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
Keywords
- Amino acid
- Amino protecting group
- DNA
- Distamycin
- Tsc group
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry