The analysis of circumsporozoite-protein gene sequences from South Korean isolates of Plasmodium vivax

C. S. Lim; Y. K. Kim; K. N. Lee; S. H. Kim; K. J. Hoffman; K. J. Song; J. W. Song

doi:10.1080/00034983.2001.11813634

The analysis of circumsporozoite-protein gene sequences from South Korean isolates of Plasmodium vivax

C. S. Lim, Y. K. Kim, K. N. Lee, S. H. Kim, K. J. Hoffman, K. J. Song, J. W. Song

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

The amino-acid sequences corresponding to the circumsporozoite protein (CSP) of Plasmodium vivax fall into two main types, VK210 and VK247, each of which has a characteristic tandem repeat. When the repetitive domains of the CSP gene from six isolates of P. vivax from South Korea were sequenced they were found to show a total of 20 tandem amino-acid repeats, and repeat patterns that are regular and distinct from those of other P. vivax isolates. The amino-acid sequences of the South Korean parasites were found to be most similar to those of three isolates from China (CH-3, CH4, and CH-5) and, particularly, to one from North Korea. A sequence (AGGNAANKKAEDAGGNA) and two repeats of the sequence GGNA found in the North Korean parasites were found in all six isolates from South Korea. The South Korean parasites investigated appear phylogenetically identical and unique to the Korean peninsula.

Original language	English
Pages (from-to)	229-235
Number of pages	7
Journal	Annals of Tropical Medicine and Parasitology
Volume	95
Issue number	3
DOIs	https://doi.org/10.1080/00034983.2001.11813634
Publication status	Published - 2001
Externally published	Yes

ASJC Scopus subject areas

Parasitology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/00034983.2001.11813634

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title = "The analysis of circumsporozoite-protein gene sequences from South Korean isolates of Plasmodium vivax",

abstract = "The amino-acid sequences corresponding to the circumsporozoite protein (CSP) of Plasmodium vivax fall into two main types, VK210 and VK247, each of which has a characteristic tandem repeat. When the repetitive domains of the CSP gene from six isolates of P. vivax from South Korea were sequenced they were found to show a total of 20 tandem amino-acid repeats, and repeat patterns that are regular and distinct from those of other P. vivax isolates. The amino-acid sequences of the South Korean parasites were found to be most similar to those of three isolates from China (CH-3, CH4, and CH-5) and, particularly, to one from North Korea. A sequence (AGGNAANKKAEDAGGNA) and two repeats of the sequence GGNA found in the North Korean parasites were found in all six isolates from South Korea. The South Korean parasites investigated appear phylogenetically identical and unique to the Korean peninsula.",

author = "Lim, {C. S.} and Kim, {Y. K.} and Lee, {K. N.} and Kim, {S. H.} and Hoffman, {K. J.} and Song, {K. J.} and Song, {J. W.}",

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doi = "10.1080/00034983.2001.11813634",

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T1 - The analysis of circumsporozoite-protein gene sequences from South Korean isolates of Plasmodium vivax

AU - Lim, C. S.

AU - Kim, Y. K.

AU - Lee, K. N.

AU - Kim, S. H.

AU - Hoffman, K. J.

AU - Song, K. J.

AU - Song, J. W.

PY - 2001

Y1 - 2001

N2 - The amino-acid sequences corresponding to the circumsporozoite protein (CSP) of Plasmodium vivax fall into two main types, VK210 and VK247, each of which has a characteristic tandem repeat. When the repetitive domains of the CSP gene from six isolates of P. vivax from South Korea were sequenced they were found to show a total of 20 tandem amino-acid repeats, and repeat patterns that are regular and distinct from those of other P. vivax isolates. The amino-acid sequences of the South Korean parasites were found to be most similar to those of three isolates from China (CH-3, CH4, and CH-5) and, particularly, to one from North Korea. A sequence (AGGNAANKKAEDAGGNA) and two repeats of the sequence GGNA found in the North Korean parasites were found in all six isolates from South Korea. The South Korean parasites investigated appear phylogenetically identical and unique to the Korean peninsula.

AB - The amino-acid sequences corresponding to the circumsporozoite protein (CSP) of Plasmodium vivax fall into two main types, VK210 and VK247, each of which has a characteristic tandem repeat. When the repetitive domains of the CSP gene from six isolates of P. vivax from South Korea were sequenced they were found to show a total of 20 tandem amino-acid repeats, and repeat patterns that are regular and distinct from those of other P. vivax isolates. The amino-acid sequences of the South Korean parasites were found to be most similar to those of three isolates from China (CH-3, CH4, and CH-5) and, particularly, to one from North Korea. A sequence (AGGNAANKKAEDAGGNA) and two repeats of the sequence GGNA found in the North Korean parasites were found in all six isolates from South Korea. The South Korean parasites investigated appear phylogenetically identical and unique to the Korean peninsula.

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U2 - 10.1080/00034983.2001.11813634

DO - 10.1080/00034983.2001.11813634

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VL - 95

SP - 229

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JO - Annals of Tropical Medicine and Parasitology

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IS - 3

ER -

The analysis of circumsporozoite-protein gene sequences from South Korean isolates of Plasmodium vivax

Abstract

ASJC Scopus subject areas

UN SDGs

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