The analysis of Plasmodium vivax Duffy receptor binding domain gene sequence from resurgent Korea isolates

In Suh; Kenneth J. Hoffman; Sang Hyun Kim; Ki Joon Song; Jin Won Song; Joon Lee; Chae Lim

doi:10.1007/s004360100478

The analysis of Plasmodium vivax Duffy receptor binding domain gene sequence from resurgent Korea isolates

In Suh, Kenneth J. Hoffman, Sang Hyun Kim, Ki Joon Song, Jin Won Song, Joon Lee, Chae Lim

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The Duffy binding domain gene structures of Plasmodium vivax facilitate the invasion of erythrocytes. Human erythrocytes that lack Duffy blood group antigens are resistant to invasion by P. vivax. We have sequenced the Duffy binding domain gene from eight P. vivax isolates collected from malaria cases in South Korea. When compared to isolates from other regions in the world, the amino acid sequences of the Korean isolates showed unique variations in region II. From 606 sequenced amino acids, 32 variations were found. Of these, three variations were regularly found in positions 424, 437 and 503 of the Sal-1 amino acid sequence. In region III, six isolates had a loss of the 30 bp (FAESTKSAE) insert. However, six isolates had 6 bp (SD) inserts at the end of region III. Two cases had a reverse pattern. Our results suggest that the P. vivax currently found in South Korea are unique when compared to other isolates and can be divided, by the analysis of their molecular structure, into two strains.

Original language	English
Pages (from-to)	1007-1010
Number of pages	4
Journal	Parasitology Research
Volume	87
Issue number	12
DOIs	https://doi.org/10.1007/s004360100478
Publication status	Published - 2001

Bibliographical note

Funding Information:
Acknowledgement This work was supported by a grant from the health technology plan of the Ministry of Health and Welfare, Republic of Korea (Grant No HMP-99-M-04–0002).

ASJC Scopus subject areas

Parasitology
General Veterinary
Insect Science
Infectious Diseases

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s004360100478

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title = "The analysis of Plasmodium vivax Duffy receptor binding domain gene sequence from resurgent Korea isolates",

abstract = "The Duffy binding domain gene structures of Plasmodium vivax facilitate the invasion of erythrocytes. Human erythrocytes that lack Duffy blood group antigens are resistant to invasion by P. vivax. We have sequenced the Duffy binding domain gene from eight P. vivax isolates collected from malaria cases in South Korea. When compared to isolates from other regions in the world, the amino acid sequences of the Korean isolates showed unique variations in region II. From 606 sequenced amino acids, 32 variations were found. Of these, three variations were regularly found in positions 424, 437 and 503 of the Sal-1 amino acid sequence. In region III, six isolates had a loss of the 30 bp (FAESTKSAE) insert. However, six isolates had 6 bp (SD) inserts at the end of region III. Two cases had a reverse pattern. Our results suggest that the P. vivax currently found in South Korea are unique when compared to other isolates and can be divided, by the analysis of their molecular structure, into two strains.",

author = "In Suh and Hoffman, {Kenneth J.} and Kim, {Sang Hyun} and Song, {Ki Joon} and Song, {Jin Won} and Joon Lee and Chae Lim",

note = "Funding Information: Acknowledgement This work was supported by a grant from the health technology plan of the Ministry of Health and Welfare, Republic of Korea (Grant No HMP-99-M-04–0002).",

year = "2001",

doi = "10.1007/s004360100478",

language = "English",

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T1 - The analysis of Plasmodium vivax Duffy receptor binding domain gene sequence from resurgent Korea isolates

AU - Suh, In

AU - Hoffman, Kenneth J.

AU - Kim, Sang Hyun

AU - Song, Ki Joon

AU - Song, Jin Won

AU - Lee, Joon

AU - Lim, Chae

N1 - Funding Information: Acknowledgement This work was supported by a grant from the health technology plan of the Ministry of Health and Welfare, Republic of Korea (Grant No HMP-99-M-04–0002).

PY - 2001

Y1 - 2001

N2 - The Duffy binding domain gene structures of Plasmodium vivax facilitate the invasion of erythrocytes. Human erythrocytes that lack Duffy blood group antigens are resistant to invasion by P. vivax. We have sequenced the Duffy binding domain gene from eight P. vivax isolates collected from malaria cases in South Korea. When compared to isolates from other regions in the world, the amino acid sequences of the Korean isolates showed unique variations in region II. From 606 sequenced amino acids, 32 variations were found. Of these, three variations were regularly found in positions 424, 437 and 503 of the Sal-1 amino acid sequence. In region III, six isolates had a loss of the 30 bp (FAESTKSAE) insert. However, six isolates had 6 bp (SD) inserts at the end of region III. Two cases had a reverse pattern. Our results suggest that the P. vivax currently found in South Korea are unique when compared to other isolates and can be divided, by the analysis of their molecular structure, into two strains.

AB - The Duffy binding domain gene structures of Plasmodium vivax facilitate the invasion of erythrocytes. Human erythrocytes that lack Duffy blood group antigens are resistant to invasion by P. vivax. We have sequenced the Duffy binding domain gene from eight P. vivax isolates collected from malaria cases in South Korea. When compared to isolates from other regions in the world, the amino acid sequences of the Korean isolates showed unique variations in region II. From 606 sequenced amino acids, 32 variations were found. Of these, three variations were regularly found in positions 424, 437 and 503 of the Sal-1 amino acid sequence. In region III, six isolates had a loss of the 30 bp (FAESTKSAE) insert. However, six isolates had 6 bp (SD) inserts at the end of region III. Two cases had a reverse pattern. Our results suggest that the P. vivax currently found in South Korea are unique when compared to other isolates and can be divided, by the analysis of their molecular structure, into two strains.

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VL - 87

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JO - Parasitology Research

JF - Parasitology Research

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The analysis of Plasmodium vivax Duffy receptor binding domain gene sequence from resurgent Korea isolates

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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