The anti-influenza virus effect of Phellinus igniarius extract

Sangmoo Lee, Jin Il Kim, Jun Heo, Ilseob Lee, Sehee Park, Min Woong Hwang, Joon Yong Bae, Mee Sook Park, Hyoung Jin Park, Man Seong Park

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

Herbal medicine has been used in the orient for thousands of years to treat large and small ailments, including microbial infections. Although there are treatments for influenza virus infection, there is no treatment for drug-resistant viruses. It is time that we explored and exploited the multi-component nature of herbal extracts as multi-drug combination therapies. Here, we present data on the anti-influenza virus effect of a medicinal mushroom, Phellinus igniarius. The P. igniarius water extract was effective against influenza A and B viruses, including 2009 pandemic H1N1, human H3N2, avian H9N2, and oseltamivir-resistant H1N1 viruses. Virological assays revealed that the extract may interfere with one or more early events in the influenza virus replication cycle, including viral attachment to the target cell. Therefore, our results provide new insights into the use of P. igniarius as an anti-influenza medicine.

Original languageEnglish
Pages (from-to)676-681
Number of pages6
JournalJournal of Microbiology
Volume51
Issue number5
DOIs
Publication statusPublished - 2013 Oct

Bibliographical note

Funding Information:
This study was supported by grants from the Korea Healthcare Technology R&D Project of the Ministry of Health & Welfare (Grant No. A103001), the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (Grant No. 2007-0052178), and the Hallym University Specialization Fund (HRF-S-41).

Keywords

  • Phellinus igniarius
  • antiviral
  • herbal
  • influenza
  • multi-drug

ASJC Scopus subject areas

  • Microbiology
  • Applied Microbiology and Biotechnology

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