TY - JOUR
T1 - The association between bisphenol a exposure and obesity in children—a systematic review with meta-analysis
AU - Kim, Ka Young
AU - Lee, Eunil
AU - Kim, Yanghee
N1 - Funding Information:
This work was supported by Korea Environment Industry and Technology Institute (KEITI) through Environmental Health Action Program, funded by Korea Ministry of Environment (MOE) (2017001360006) and the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP: Ministry of Science, ICT and Future Planning) (2017R1C1B5017938).
Funding Information:
Funding: This work was supported by Korea Environment Industry and Technology Institute (KEITI) through Environmental Health Action Program, funded by Korea Ministry of Environment (MOE) (2017001360006) and the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP: Ministry of Science, ICT and Future Planning) (2017R1C1B5017938).
Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland
PY - 2019/7/2
Y1 - 2019/7/2
N2 - Bisphenol A (BPA) is an environmental chemical that has adverse effects on health, probably causing childhood obesity. However, this association remains controversial, and it is difficult to find evidence for direct causality between environmental exposure and disease using epidemiological studies. In this study, we sought to elucidate the possible causality between BPA exposure and childhood obesity by conducting two meta-analyses showing bidirectional associations, including exposure effect by obesity and obesity risk by exposure. Articles published up to September 2017 were searched in PubMed, Embase, and Cochrane Library. We evaluated observational studies that included measurements of urinary BPA concentration and BMI or body weight. Of 436 articles, a total of 13 studies were included in the meta-analysis. Two meta-analyses were performed to investigate the association between BPA exposure and childhood obesity. The results showed that the relatively high-exposed group had a significantly higher risk of childhood obesity than the relatively low-exposed group (odds ratio = 1.566, 95% confidence interval [CI]: 1.097 to 2.234, p = 0.014). However, the obese group showed no significant difference in the BPA concentration when compared to the normal group (standardized mean difference = 0.166, 95% CI: −0.121 to 0.453, p = 0.257). This study suggested possible causality between BPA exposure and childhood obesity using data from epidemiological studies and showed that BPA exposure itself increased the risk of obesity in children.
AB - Bisphenol A (BPA) is an environmental chemical that has adverse effects on health, probably causing childhood obesity. However, this association remains controversial, and it is difficult to find evidence for direct causality between environmental exposure and disease using epidemiological studies. In this study, we sought to elucidate the possible causality between BPA exposure and childhood obesity by conducting two meta-analyses showing bidirectional associations, including exposure effect by obesity and obesity risk by exposure. Articles published up to September 2017 were searched in PubMed, Embase, and Cochrane Library. We evaluated observational studies that included measurements of urinary BPA concentration and BMI or body weight. Of 436 articles, a total of 13 studies were included in the meta-analysis. Two meta-analyses were performed to investigate the association between BPA exposure and childhood obesity. The results showed that the relatively high-exposed group had a significantly higher risk of childhood obesity than the relatively low-exposed group (odds ratio = 1.566, 95% confidence interval [CI]: 1.097 to 2.234, p = 0.014). However, the obese group showed no significant difference in the BPA concentration when compared to the normal group (standardized mean difference = 0.166, 95% CI: −0.121 to 0.453, p = 0.257). This study suggested possible causality between BPA exposure and childhood obesity using data from epidemiological studies and showed that BPA exposure itself increased the risk of obesity in children.
KW - Bisphenol A (BPA)
KW - Childhood
KW - Meta-analysis
KW - Obesity
KW - Systematic review
UR - http://www.scopus.com/inward/record.url?scp=85070004094&partnerID=8YFLogxK
U2 - 10.3390/ijerph16142521
DO - 10.3390/ijerph16142521
M3 - Article
C2 - 31311074
AN - SCOPUS:85070004094
SN - 1661-7827
VL - 16
JO - International journal of environmental research and public health
JF - International journal of environmental research and public health
IS - 14
M1 - 2521
ER -
