TY - JOUR
T1 - The association between the PTPN22 C1858T polymorphism and systemic lupus erythematosus
T2 - A meta-analysis update
AU - Lea, W. W.
AU - Lee, Y. H.
PY - 2011/1
Y1 - 2011/1
N2 - The aim of this study was to determine whether the functional protein tyrosine phosphatase nonreceptor 22 (PTPN22) C1858T polymorphism (rs2476601) confers susceptibility to systemic lupus erythematosus (SLE) in ethnically different populations. A meta-analysis was conducted on the PTPN22 C1858T polymorphism across 11 comparative studies. Meta-analysis showed an association between the PTPN22 1858T allele and SLE in all study subjects (odds ratio (OR) 1.560, 95% confidence interval (CI) 1.336, 1.822, p = 2.0 × 10 -8). Analysis after stratification by ethnicity indicated that the PTPN22 1858T allele was significantly associated with SLE in Europeans and Hispanics (OR 1.490, 95% CI 1.280, 1.735, p = 2.0 × 10-8; OR 2.355, 95% CI 1.644, 3.373, p = 2.9 × 10-6). The meta-analysis showed that the C/T + T/T genotype was associated with susceptibility to SLE in all study subjects, Europeans, and Hispanics populations, and an association between the T/T genotype with SLE in Europeans. African Americans had a much lower prevalence of the T allele (2.2%) than any other population studied, and Europeans had the highest frequency (9.5%). In conclusion, this meta-analysis confirms that the PTPN22 C1858T polymorphism is associated with SLE susceptibility in different ethnic groups, and that its prevalence is ethnicity dependent. Lupus (2011) 20, 51-57.
AB - The aim of this study was to determine whether the functional protein tyrosine phosphatase nonreceptor 22 (PTPN22) C1858T polymorphism (rs2476601) confers susceptibility to systemic lupus erythematosus (SLE) in ethnically different populations. A meta-analysis was conducted on the PTPN22 C1858T polymorphism across 11 comparative studies. Meta-analysis showed an association between the PTPN22 1858T allele and SLE in all study subjects (odds ratio (OR) 1.560, 95% confidence interval (CI) 1.336, 1.822, p = 2.0 × 10 -8). Analysis after stratification by ethnicity indicated that the PTPN22 1858T allele was significantly associated with SLE in Europeans and Hispanics (OR 1.490, 95% CI 1.280, 1.735, p = 2.0 × 10-8; OR 2.355, 95% CI 1.644, 3.373, p = 2.9 × 10-6). The meta-analysis showed that the C/T + T/T genotype was associated with susceptibility to SLE in all study subjects, Europeans, and Hispanics populations, and an association between the T/T genotype with SLE in Europeans. African Americans had a much lower prevalence of the T allele (2.2%) than any other population studied, and Europeans had the highest frequency (9.5%). In conclusion, this meta-analysis confirms that the PTPN22 C1858T polymorphism is associated with SLE susceptibility in different ethnic groups, and that its prevalence is ethnicity dependent. Lupus (2011) 20, 51-57.
KW - meta-analysis
KW - polymorphism
KW - protein tyrosine phosphatase nonreceptor 22
KW - systemic lupus erythematosus
UR - http://www.scopus.com/inward/record.url?scp=78751497823&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78751497823&partnerID=8YFLogxK
U2 - 10.1177/0961203310381774
DO - 10.1177/0961203310381774
M3 - Article
C2 - 21078766
AN - SCOPUS:78751497823
SN - 0961-2033
VL - 20
SP - 51
EP - 57
JO - Lupus
JF - Lupus
IS - 1
ER -