The association of low muscle mass with soluble receptor for advanced glycation end products (sRAGE): The Korean Sarcopenic Obesity Study (KSOS)

Tae Nyun Kim; Man Sik Park; Eun Joo Lee; Hye Soo Chung; Hye Jin Yoo; Hyun Joo Kang; Wook Song; Sei Hyun Baik; Kyung Mook Choi

doi:10.1002/dmrr.2974

The association of low muscle mass with soluble receptor for advanced glycation end products (sRAGE): The Korean Sarcopenic Obesity Study (KSOS)

Tae Nyun Kim, Man Sik Park, Eun Joo Lee, Hye Soo Chung, Hye Jin Yoo, Hyun Joo Kang, Wook Song, Sei Hyun Baik, Kyung Mook Choi

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Background: Advanced glycation end products (AGEs) are accumulated with aging in various tissues of humans. The soluble receptor for AGEs (sRAGE) exerts a protective role against the development of aging-related chronic disorders by neutralizing the action of AGEs. We investigated the implication of sRAGE on low muscle mass in Asian men and women. Methods: This cross-sectional study included a 390-participant, nondiabetic subcohort recruited within the framework of the Korean Sarcopenic Obesity Study, an ongoing prospective cohort study. Low muscle mass was defined based on the distribution of appendicular skeletal muscle mass divided by body mass index, as proposed by the Foundation for the National Institutes Sarcopenia Project. Results: Serum sRAGE levels were significantly lower in participants with low muscle mass than in participants without low muscle mass (0.76 [0.60-1.00] ng/mL vs 0.87 [0.67-1.15] ng/mL, P =.005). In age- and sex-adjusted correlation analyses, appendicular skeletal muscle mass divided by body mass index was associated with sRAGE (r = 0.109, P =.037). Furthermore, decreased circulating levels of sRAGE are independently associated with low muscle mass (odds ratio = 0.254, P =.002) after adjusting for confounding factors, including insulin resistance and inflammatory markers. Conclusions: The present study shows that a low circulating level of sRAGE may be an independent risk factor for the presence of low muscle mass.

Original language	English
Article number	e2974
Journal	Diabetes/Metabolism Research and Reviews
Volume	34
Issue number	3
DOIs	https://doi.org/10.1002/dmrr.2974
Publication status	Published - 2018 Mar

Bibliographical note

Funding Information:
The Korean Sarcopenic Obesity Study (KSOS), which was supported by the Korea Science and Engineering Foundation, was a longitudinal, observational study of 1027 well‐functioning men and women recruited in 2007‐2009. This prospective observational cohort study was designed to examine the prevalence of sarcopenia in Korean adults and to evaluate its effects on metabolic disorders and health outcomes.15-17 The KSOS study is composed of nondiabetic and diabetic subcohorts and a young reference group. The present study recruited eligible participants over 40 years of age with no history of any type of diabetes, cardiovascular disease (myocardial infarction, unstable angina, stroke, or cardiovascular revascularization), stage 2 hypertension (resting blood pressure, ≥160/100 mm Hg), malignant disease, or severe renal or hepatic disease. Among 442 participants in the nondiabetic subcohort with complete demographic data, we excluded participants without complete clinical laboratory measures or body composition measures. Ultimately, 390 participants (153 men and 237 women) with complete clinical laboratory data and body composition data were included for this study. Participants who exercised regularly at a moderate intensity were asked about the frequency with which they exercised per week, and the length of time per exercise session. Regular exercise was defined as exercising 5 or more times per week.17 Smoking status was divided into 3 categories: current smoker, ex‐smoker, and nonsmoker. All participants provided written informed consent, and the Korea University Institutional Review Board, in accordance with the Declaration of Helsinki of the World Medical Association, approved the study protocol.

Funding Information:
Dr KMC was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), which is funded by the Ministry of Education, Science and Technology (2015R1D1A1A09057389). Dr TNK was supported by Priority Research Centers Program through the NRF funded by the Ministry of Education, Science and Technology (2010‐0020224). The content is solely the responsibility of the authors and does not necessarily represent the official views of the sponsors.

Funding Information:
The Basic Science Research Program through the National Research Foundation of Korea (NRF), Grant/Award Number: 2015R1D1A1A09057389; Priority Research Centers Program through the NRF, Grant/ Award Number: 2010‐0020224

Publisher Copyright:
Copyright © 2017 John Wiley & Sons, Ltd.

Keywords

body composition
low muscle mass
sRAGE
sarcopenia

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/dmrr.2974

Cite this

@article{8209b15768564383bb40e73f29738f6f,

title = "The association of low muscle mass with soluble receptor for advanced glycation end products (sRAGE): The Korean Sarcopenic Obesity Study (KSOS)",

abstract = "Background: Advanced glycation end products (AGEs) are accumulated with aging in various tissues of humans. The soluble receptor for AGEs (sRAGE) exerts a protective role against the development of aging-related chronic disorders by neutralizing the action of AGEs. We investigated the implication of sRAGE on low muscle mass in Asian men and women. Methods: This cross-sectional study included a 390-participant, nondiabetic subcohort recruited within the framework of the Korean Sarcopenic Obesity Study, an ongoing prospective cohort study. Low muscle mass was defined based on the distribution of appendicular skeletal muscle mass divided by body mass index, as proposed by the Foundation for the National Institutes Sarcopenia Project. Results: Serum sRAGE levels were significantly lower in participants with low muscle mass than in participants without low muscle mass (0.76 [0.60-1.00] ng/mL vs 0.87 [0.67-1.15] ng/mL, P =.005). In age- and sex-adjusted correlation analyses, appendicular skeletal muscle mass divided by body mass index was associated with sRAGE (r = 0.109, P =.037). Furthermore, decreased circulating levels of sRAGE are independently associated with low muscle mass (odds ratio = 0.254, P =.002) after adjusting for confounding factors, including insulin resistance and inflammatory markers. Conclusions: The present study shows that a low circulating level of sRAGE may be an independent risk factor for the presence of low muscle mass.",

keywords = "body composition, low muscle mass, sRAGE, sarcopenia",

author = "Kim, {Tae Nyun} and Park, {Man Sik} and Lee, {Eun Joo} and Chung, {Hye Soo} and Yoo, {Hye Jin} and Kang, {Hyun Joo} and Wook Song and Baik, {Sei Hyun} and Choi, {Kyung Mook}",

note = "Funding Information: The Korean Sarcopenic Obesity Study (KSOS), which was supported by the Korea Science and Engineering Foundation, was a longitudinal, observational study of 1027 well‐functioning men and women recruited in 2007‐2009. This prospective observational cohort study was designed to examine the prevalence of sarcopenia in Korean adults and to evaluate its effects on metabolic disorders and health outcomes.15-17 The KSOS study is composed of nondiabetic and diabetic subcohorts and a young reference group. The present study recruited eligible participants over 40 years of age with no history of any type of diabetes, cardiovascular disease (myocardial infarction, unstable angina, stroke, or cardiovascular revascularization), stage 2 hypertension (resting blood pressure, ≥160/100 mm Hg), malignant disease, or severe renal or hepatic disease. Among 442 participants in the nondiabetic subcohort with complete demographic data, we excluded participants without complete clinical laboratory measures or body composition measures. Ultimately, 390 participants (153 men and 237 women) with complete clinical laboratory data and body composition data were included for this study. Participants who exercised regularly at a moderate intensity were asked about the frequency with which they exercised per week, and the length of time per exercise session. Regular exercise was defined as exercising 5 or more times per week.17 Smoking status was divided into 3 categories: current smoker, ex‐smoker, and nonsmoker. All participants provided written informed consent, and the Korea University Institutional Review Board, in accordance with the Declaration of Helsinki of the World Medical Association, approved the study protocol. Funding Information: Dr KMC was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), which is funded by the Ministry of Education, Science and Technology (2015R1D1A1A09057389). Dr TNK was supported by Priority Research Centers Program through the NRF funded by the Ministry of Education, Science and Technology (2010‐0020224). The content is solely the responsibility of the authors and does not necessarily represent the official views of the sponsors. Funding Information: The Basic Science Research Program through the National Research Foundation of Korea (NRF), Grant/Award Number: 2015R1D1A1A09057389; Priority Research Centers Program through the NRF, Grant/ Award Number: 2010‐0020224 Publisher Copyright: Copyright {\textcopyright} 2017 John Wiley & Sons, Ltd.",

year = "2018",

month = mar,

doi = "10.1002/dmrr.2974",

language = "English",

volume = "34",

journal = "Diabetes/Metabolism Research and Reviews",

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T1 - The association of low muscle mass with soluble receptor for advanced glycation end products (sRAGE)

T2 - The Korean Sarcopenic Obesity Study (KSOS)

AU - Kim, Tae Nyun

AU - Park, Man Sik

AU - Lee, Eun Joo

AU - Chung, Hye Soo

AU - Yoo, Hye Jin

AU - Kang, Hyun Joo

AU - Song, Wook

AU - Baik, Sei Hyun

AU - Choi, Kyung Mook

N1 - Funding Information: The Korean Sarcopenic Obesity Study (KSOS), which was supported by the Korea Science and Engineering Foundation, was a longitudinal, observational study of 1027 well‐functioning men and women recruited in 2007‐2009. This prospective observational cohort study was designed to examine the prevalence of sarcopenia in Korean adults and to evaluate its effects on metabolic disorders and health outcomes.15-17 The KSOS study is composed of nondiabetic and diabetic subcohorts and a young reference group. The present study recruited eligible participants over 40 years of age with no history of any type of diabetes, cardiovascular disease (myocardial infarction, unstable angina, stroke, or cardiovascular revascularization), stage 2 hypertension (resting blood pressure, ≥160/100 mm Hg), malignant disease, or severe renal or hepatic disease. Among 442 participants in the nondiabetic subcohort with complete demographic data, we excluded participants without complete clinical laboratory measures or body composition measures. Ultimately, 390 participants (153 men and 237 women) with complete clinical laboratory data and body composition data were included for this study. Participants who exercised regularly at a moderate intensity were asked about the frequency with which they exercised per week, and the length of time per exercise session. Regular exercise was defined as exercising 5 or more times per week.17 Smoking status was divided into 3 categories: current smoker, ex‐smoker, and nonsmoker. All participants provided written informed consent, and the Korea University Institutional Review Board, in accordance with the Declaration of Helsinki of the World Medical Association, approved the study protocol. Funding Information: Dr KMC was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), which is funded by the Ministry of Education, Science and Technology (2015R1D1A1A09057389). Dr TNK was supported by Priority Research Centers Program through the NRF funded by the Ministry of Education, Science and Technology (2010‐0020224). The content is solely the responsibility of the authors and does not necessarily represent the official views of the sponsors. Funding Information: The Basic Science Research Program through the National Research Foundation of Korea (NRF), Grant/Award Number: 2015R1D1A1A09057389; Priority Research Centers Program through the NRF, Grant/ Award Number: 2010‐0020224 Publisher Copyright: Copyright © 2017 John Wiley & Sons, Ltd.

PY - 2018/3

Y1 - 2018/3

N2 - Background: Advanced glycation end products (AGEs) are accumulated with aging in various tissues of humans. The soluble receptor for AGEs (sRAGE) exerts a protective role against the development of aging-related chronic disorders by neutralizing the action of AGEs. We investigated the implication of sRAGE on low muscle mass in Asian men and women. Methods: This cross-sectional study included a 390-participant, nondiabetic subcohort recruited within the framework of the Korean Sarcopenic Obesity Study, an ongoing prospective cohort study. Low muscle mass was defined based on the distribution of appendicular skeletal muscle mass divided by body mass index, as proposed by the Foundation for the National Institutes Sarcopenia Project. Results: Serum sRAGE levels were significantly lower in participants with low muscle mass than in participants without low muscle mass (0.76 [0.60-1.00] ng/mL vs 0.87 [0.67-1.15] ng/mL, P =.005). In age- and sex-adjusted correlation analyses, appendicular skeletal muscle mass divided by body mass index was associated with sRAGE (r = 0.109, P =.037). Furthermore, decreased circulating levels of sRAGE are independently associated with low muscle mass (odds ratio = 0.254, P =.002) after adjusting for confounding factors, including insulin resistance and inflammatory markers. Conclusions: The present study shows that a low circulating level of sRAGE may be an independent risk factor for the presence of low muscle mass.

AB - Background: Advanced glycation end products (AGEs) are accumulated with aging in various tissues of humans. The soluble receptor for AGEs (sRAGE) exerts a protective role against the development of aging-related chronic disorders by neutralizing the action of AGEs. We investigated the implication of sRAGE on low muscle mass in Asian men and women. Methods: This cross-sectional study included a 390-participant, nondiabetic subcohort recruited within the framework of the Korean Sarcopenic Obesity Study, an ongoing prospective cohort study. Low muscle mass was defined based on the distribution of appendicular skeletal muscle mass divided by body mass index, as proposed by the Foundation for the National Institutes Sarcopenia Project. Results: Serum sRAGE levels were significantly lower in participants with low muscle mass than in participants without low muscle mass (0.76 [0.60-1.00] ng/mL vs 0.87 [0.67-1.15] ng/mL, P =.005). In age- and sex-adjusted correlation analyses, appendicular skeletal muscle mass divided by body mass index was associated with sRAGE (r = 0.109, P =.037). Furthermore, decreased circulating levels of sRAGE are independently associated with low muscle mass (odds ratio = 0.254, P =.002) after adjusting for confounding factors, including insulin resistance and inflammatory markers. Conclusions: The present study shows that a low circulating level of sRAGE may be an independent risk factor for the presence of low muscle mass.

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The association of low muscle mass with soluble receptor for advanced glycation end products (sRAGE): The Korean Sarcopenic Obesity Study (KSOS)

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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