Abstract
Backgrounds: Substance P, which is encoded by tachykinin precursor 1 gene (TAC1), has been implicated in the regulation of stress responses and the pathogenesis of major depressive disorder (MDD). Methods: We evaluated the association of 10 SNPs on TAC1 with MDD susceptibility in 111 patients with MDD and 79 control subjects, and with 17-item Hamilton depression rating scale (HAMD17) score in MDD patients. Results: In all subjects, haplotype (ht) 2 homozygous individuals showed higher plasma substance P levels than subjects carrying one or no copy of ht2. The minor allele frequency of rs1397202 was higher in patients with MDD than that in control subjects. Patients homozygous for the minor allele of rs1397202 showed significantly lower HAMD17 scores than patients carrying the common allele. Conclusion: Our results suggest a possible involvement of genetic variants of TAC1 with the plasma level of substance P and symptom severity of MDD.
| Original language | English |
|---|---|
| Pages (from-to) | 129-136 |
| Number of pages | 8 |
| Journal | Molecular and Cellular Toxicology |
| Volume | 15 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2019 Apr 1 |
Bibliographical note
Publisher Copyright:© 2019, The Korean Society of Toxicogenomics and Toxicoproteomics and Springer Nature B.V.
Keywords
- Major depressive disorder
- Substance P
- Tachykinin precursor 1 gene
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- General Pharmacology, Toxicology and Pharmaceutics
- Health, Toxicology and Mutagenesis
- Pathology and Forensic Medicine
- Toxicology
