The binding of fluorophores to proteins depends on the cellular environment

Yun Kyung Kim; Jun Seok Lee; Xuezhi Bi; Hyung Ho Ha; Shin Hui Ng; Young Hoon Ahn; Jae Jung Lee; Bridget K. Wagner; Paul A. Clemons; Young Tae Chang

doi:10.1002/anie.201007626

The binding of fluorophores to proteins depends on the cellular environment

Yun Kyung Kim, Jun Seok Lee, Xuezhi Bi, Hyung Ho Ha, Shin Hui Ng, Young Hoon Ahn, Jae Jung Lee, Bridget K. Wagner, Paul A. Clemons, Young Tae Chang

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

Lighten up! To investigate intracellular binders of myotube-specific probes, a thiol-reactive derivative, CDy2, was prepared. In live cells, the derivative selectively localizes in mitochondria and covalently labels its binding partners.

Original language	English
Pages (from-to)	2761-2763
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	12
DOIs	https://doi.org/10.1002/anie.201007626
Publication status	Published - 2011 Mar 14
Externally published	Yes

Keywords

fluorescent probes
imaging agents
live-cell imaging
mitochondria
rosamine

ASJC Scopus subject areas

Catalysis
Chemistry(all)

Access to Document

10.1002/anie.201007626

Cite this

@article{8a1a99e986f24b35ab6a199139744197,

title = "The binding of fluorophores to proteins depends on the cellular environment",

abstract = "Lighten up! To investigate intracellular binders of myotube-specific probes, a thiol-reactive derivative, CDy2, was prepared. In live cells, the derivative selectively localizes in mitochondria and covalently labels its binding partners.",

keywords = "fluorescent probes, imaging agents, live-cell imaging, mitochondria, rosamine",

author = "Kim, {Yun Kyung} and Lee, {Jun Seok} and Xuezhi Bi and Ha, {Hyung Ho} and Ng, {Shin Hui} and Ahn, {Young Hoon} and Lee, {Jae Jung} and Wagner, {Bridget K.} and Clemons, {Paul A.} and Chang, {Young Tae}",

year = "2011",

month = mar,

day = "14",

doi = "10.1002/anie.201007626",

language = "English",

volume = "50",

pages = "2761--2763",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "12",

}

TY - JOUR

T1 - The binding of fluorophores to proteins depends on the cellular environment

AU - Kim, Yun Kyung

AU - Lee, Jun Seok

AU - Bi, Xuezhi

AU - Ha, Hyung Ho

AU - Ng, Shin Hui

AU - Ahn, Young Hoon

AU - Lee, Jae Jung

AU - Wagner, Bridget K.

AU - Clemons, Paul A.

AU - Chang, Young Tae

PY - 2011/3/14

Y1 - 2011/3/14

N2 - Lighten up! To investigate intracellular binders of myotube-specific probes, a thiol-reactive derivative, CDy2, was prepared. In live cells, the derivative selectively localizes in mitochondria and covalently labels its binding partners.

AB - Lighten up! To investigate intracellular binders of myotube-specific probes, a thiol-reactive derivative, CDy2, was prepared. In live cells, the derivative selectively localizes in mitochondria and covalently labels its binding partners.

KW - fluorescent probes

KW - imaging agents

KW - live-cell imaging

KW - mitochondria

KW - rosamine

UR - http://www.scopus.com/inward/record.url?scp=79952491398&partnerID=8YFLogxK

U2 - 10.1002/anie.201007626

DO - 10.1002/anie.201007626

M3 - Article

C2 - 21370369

AN - SCOPUS:79952491398

SN - 1433-7851

VL - 50

SP - 2761

EP - 2763

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 12

ER -

The binding of fluorophores to proteins depends on the cellular environment

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this